Advances in the treatment of locally advanced non-nasopharyngeal squamous cell carcinoma of the head and neck region.

Medical Oncology
Amanda Psyrri, George Fountzilas

Abstract

Over the past decade important advances have been made in the treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN). Traditionally, chemotherapy has been incorporated in the treatment of SCCHN either before local treatment as induction, concomitantly with radiation, or following local treatment as adjuvant therapy. A number of randomized trials and meta-analyses have demonstrated that induction chemotherapy (usually based on the combination of cisplatin and 5-d continuous infusion of fluorouracil) followed by local treatment or concomitant chemoradiotherapy (CCRT) each prolongs survival and results in organ preservation in a significant number of patients. Survival rates appear to be higher when CCRT with cisplatin is used. Furthermore, accelerated fractionation radiation regimens have shown improved local control rates in randomized trials. Recently, new therapeutic strategies such as induction chemotherapy followed by CCRT or the incorporation of newer agents such as taxanes are under intense investigation and preliminary results are promising. Advances in molecular biology have led to the elucidation of molecular mechanisms that initiate and maintain the malignant phenotype in SCCHN. The identifi...Continue Reading

Citations

Mar 1, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·S K Kundu, M Nestor
Nov 15, 2011·International Journal of Oncology·Shunsuke IshimotoYoshinori Kamisaki
Mar 18, 2008·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jiri SimekJindrich Pazdera
Jan 19, 2012·International Reviews of Immunology·Christopher SchuttMaurizio Chiriva-Internati
Aug 28, 2009·Expert Opinion on Pharmacotherapy·Daris FerrariPaolo Foa
Oct 8, 2013·Expert Opinion on Emerging Drugs·Paolo BossiLisa Licitra
Apr 11, 2009·Oral Oncology·Yuan-Wu ChenHuey-Kang Sytwu
Mar 16, 2011·Cancer Science·Morio KusayamaYoshinori Kamisaki
Jul 3, 2009·Journal of Pharmacological Sciences·Masahide NagataYoshinori Kamisaki
Jun 23, 2015·PloS One·Ludmila Madeira Cardoso PavanEliete Neves Silva Guerra
Apr 20, 2007·International Journal of Clinical Oncology·Juliette ThariatK Kian Ang

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