Advances in the Treatment of Oligometastatic Disease: What the Radiologist Needs to Know to Guide Patient Management

Academic Radiology
Steven P RowePamela T Johnson

Abstract

An ever-expanding body of biological, genetic, and clinical evidence has brought to light the presence of the oligometastatic state of cancer, which is considered between localized disease and widespread metastases. Indeed, in some patients with oligometastatic disease, curative therapy is possible. For select cancer histologies, aggressive focal therapy of oligometastatic lesions is already the clinical standard of care (i.e. colorectal cancer and sarcomas), while for other tumor types the evidence is still emerging (i.e. prostate, breast, etc.). It is increasingly important, therefore, for the radiologist interpreting oncology patients' staging or restaging examinations to be aware of those diseases for which targeted therapy of oligometastases may be undertaken to effectively guide such management. The improved imaging resolution provided by technological advances promise to aid in the detection of subtle sites of disease to ensure the identification of patients with oligometastases amenable to targeted treatment.

References

Mar 28, 2001·The Annals of Thoracic Surgery·H PorteA Wurtz
Sep 24, 2004·Archives of Surgery·Richard EssnerDonald L Morton
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James S TomlinsonMichael D'Angelica
Mar 12, 2010·Journal of the National Cancer Institute·Olivia PaganiUNKNOWN ESO-MBC Task Force
Mar 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly S CorbinRalph R Weichselbaum
Sep 21, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Allison AshworthDavid Palma
Oct 11, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·A T FalkUNKNOWN Groupe Sarcome Francais-Groupe D'etude Des Tumeurs Osseuses
Dec 3, 2014·The Lancet Oncology·Saeed DabestaniAxel Bex
Dec 17, 2014·Radiation Oncology·Antonio José Conde MorenoMaría Albert Antequera
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 22, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zsolt SzaboMartin G Pomper
May 8, 2015·Cancer Metastasis Reviews·Joseph K Salama, Steven E Schild
May 28, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Markus DietleinBernd Neumaier
Sep 22, 2015·The Cancer Journal·Chad G RusthovenLaurie E Gaspar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.