Advances in the treatment of severe alcoholic hepatitis

Current Medical Research and Opinion
Wenjun WangYanhang Gao

Abstract

Severe alcoholic hepatitis (SAH) is a costly and worldwide public health issue with high morbidity and mortality. Specific effective treatments for SAH have yet to be established. The aim of the present article is to review the current knowledge of the pathogenesis, assessment and treatment options in patients with SAH. To date, alcohol abstinence and enteral nutrition are the recommended first-line treatments. Although corticosteroids remain the preferred therapy for certain patients with a modified Maddrey discriminant function level greater than 54, they only improve short-term survival rates. New research focuses on liver inflammation, liver regeneration, the gut-liver axis, human induced pluripotent stem cells and extracorporeal albumin dialysis. Liver transplantation is considered the last medical option for patients with SAH who are nonresponsive to other medical treatments.

References

Jul 13, 2004·Journal of Hepatology·Mads Kamper-JørgensenUlrik Becker
Jun 10, 2008·International Journal of Clinical Pharmacology and Therapeutics·W G Struff, G Sprotte
Sep 22, 2009·Gastroenterology·Kymberly D S WattGregory J Gores
Oct 27, 2009·European Journal of Gastroenterology & Hepatology·Judith M MorrisEwan H Forrest
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
May 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua LiuYoon-Young Jang
Sep 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sung Hwan KiBin Gao
Aug 9, 2011·Cellular & Molecular Immunology·Md A NahidEdward Kl Chan
Sep 17, 2011·Gastroenterology·Bin Gao, Ramon Bataller
Nov 11, 2011·The New England Journal of Medicine·Eric Nguyen-KhacUNKNOWN AAH-NAC Study Group
Jun 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shashi BalaGyongyi Szabo
Oct 13, 2012·Journal of Ethnopharmacology·Ren-Bo DingJian-Bo Wan
Dec 6, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rafael BañaresUNKNOWN RELIEF study group
May 11, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christopher B ForsythAli Keshavarzian
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benoit ChassaingAndrew T Gewirtz
Sep 13, 2013·JAMA : the Journal of the American Medical Association·Philippe MathurinThong Dao
Sep 21, 2013·Digestive Diseases and Sciences·Kenya KamimuraYutaka Aoyagi
Oct 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Partha MukhopadhyayPal Pacher
Nov 26, 2013·Biochemical and Biophysical Research Communications·Weibin WuJianxin Gu
Jan 21, 2014·Gastroenterology·José AltamiranoRamón Bataller
Apr 23, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Fernando J BarreyroGregory J Gores
May 23, 2014·Journal of Hepatology·Seung Ha ParkUNKNOWN Korean Association for the Study of the Liver (KASL)-Alcohol Related Problems Study Group
Jun 18, 2014·The American Journal of Gastroenterology·Virendra SinghRatiram Sharma
Jul 11, 2014·World Journal of Gastroenterology : WJG·Albert Parés, Antoni Mas
Aug 27, 2014·Alcoholism, Clinical and Experimental Research·Dora LippaiGyongyi Szabo
Sep 10, 2014·The American Journal of Gastroenterology·Richard Moreau, Pierre-Emmanuel Rautou
Sep 19, 2014·World Journal of Gastroenterology : WJG·Mohamed ShoreibahAshwani K Singal
Oct 31, 2014·World Journal of Gastroenterology : WJG·Eduardo Madrigal-SantillánJosé A Morales-González
Dec 3, 2014·Gastroenterology·Gyongyi Szabo
Mar 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Javier MichelenaRamón Bataller
Apr 5, 2015·Expert Opinion on Drug Discovery·Christine LinSalman R Khetani
May 7, 2015·World Journal of Gastroenterology : WJG·Fátima Higuera-de la TijeraJosé L Pérez-Hernández
Jun 13, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·José Luiz Marques-RochaAmelia Marti
Oct 27, 2015·World Journal of Gastroenterology : WJG·José Ursic-BedoyaGeorges-Philippe Pageaux
Dec 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G Y ImT D Schiano
Jan 31, 2016·Gastroenterology·Bin Gao, Hidekazu Tsukamoto
Mar 5, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pranoti MandrekarBin Gao

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