Advances in the treatment of systemic lupus erythematosus: From back to the future, to the future and beyond

Joint, Bone, Spine : Revue Du Rhumatisme
Renaud FeltenLaurent Arnaud

Abstract

There have been many advances in the diagnosis and therapeutic management of systemic lupus erythematosus (SLE) over the past decades. Following more than eleven centuries of therapeutic uncertainty, the discovery of the therapeutic properties of glucocorticoids is without any doubt one of the most significant advance in the field of autoimmune diseases. The many progresses made by rapidly growing chemical industry of the 19th century chemistry have allowed the identification of valuable therapeutic compounds such as anti-malarials, cyclophosphamide, azathioprine, cyclosporine and later mycophenolate mofetil, which have all profoundly changed the face of the disease. A very visible consequence of this is the profound improvement in the prognosis of the disease, with 10-year survival rates of more than 90% in most dedicated centres. Following the development of biotherapies in rheumatoid arthritis, the late 20th century has slowly opened a new era for the treatment of SLE, that of targeted therapies. With the approval of belimumab in 2011 and 74 targeted therapies in clinical development, we may expect great changes in the therapeutic management of SLE. Those molecules target inflammatory cytokines or chemokines and their recept...Continue Reading

References

Jan 1, 1975·Arthritis and Rheumatism·E GinzlerD Kaplan
Feb 29, 1992·Lancet·D BessisJ J Guilhou
Mar 6, 1986·The New England Journal of Medicine·H A AustinJ L Decker
Sep 1, 1971·Arthritis and Rheumatism·M SztejnbokD Kaplan
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ZhangT Zhou
May 1, 1954·A.M.A. Archives of Internal Medicine·E L DUBOIS
Jun 1, 1956·A.M.A. Archives of Dermatology·H M LEWIS, G M FRUMESS
Mar 5, 2004·The New England Journal of Medicine·Gabriel ContrerasDavid Roth
Feb 28, 2007·Annals of the Rheumatic Diseases·Nathalie Costedoat-ChalumeauJean-Charles Piette
May 30, 2009·Arthritis and Rheumatism·Guillermo J Pons-EstelUNKNOWN Lumina Study Group
Sep 16, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xiao LiNan Chen
Oct 29, 2011·Autoimmunity Reviews·Cándido Díaz-LagaresUNKNOWN UK-BIOGEAS Registry
Nov 18, 2011·The New England Journal of Medicine·Mary Anne DooleyUNKNOWN ALMS Group
Jul 6, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc WeidenbuschHans-Joachim Anders
Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Aug 31, 2012·Arthritis and Rheumatism·Michelle PetriLaurence S Magder
Dec 12, 2012·Arthritis Research & Therapy·Josefina Cortés-HernándezJosep Ordi-Ros
Dec 13, 2012·Autoimmunity Reviews·Remco K M A C LuijtenRonald H W M Derksen
Feb 5, 2015·Journal of the American Academy of Dermatology·François ChassetLaurent Arnaud
May 18, 2016·Journal of the American Academy of Dermatology·Feriel FenniraCamille Francès
Dec 10, 2016·Lupus Science & Medicine·Diane ApostolopoulosEric F Morand

❮ Previous
Next ❯

Citations

Aug 26, 2020·Lupus·Juan Carlos Hernández-RodríguezJose Juan Pereyra-Rodríguez
Oct 3, 2020·Inflammopharmacology·Alireza HejratiParisa Zafari
Apr 10, 2020·Current Pharmaceutical Design·Tarique HussainDildar H Kalhoro
Nov 17, 2020·Surgical Neurology International·Sarah Bin AbdulqaderGmaan Alzhrani
Dec 10, 2020·Therapeutic Advances in Musculoskeletal Disease·Hiurma Sánchez-PérezIván Ferraz-Amaro
Mar 31, 2020·Joint, Bone, Spine : Revue Du Rhumatisme·Renaud Felten, Laurent Arnaud
May 8, 2020·Journal of the American Academy of Dermatology·Renaud FeltenLaurent Arnaud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

The Journal of the Association of Physicians of India
Anjali G RajadhyakshaMilind Y Nadkar
Mini Reviews in Medicinal Chemistry
Noriko Iikuni, Antonio La Cava
Annals of the New York Academy of Sciences
Mindy S Lo, George C Tsokos
© 2022 Meta ULC. All rights reserved