Advances in the treatment of testicular cancer.

Drugs
Hans-Georg KoppJ T Hartmann

Abstract

Testicular cancer is the most common solid tumour in young men, and the treatment of testicular germ cell tumours (TGCT) has been called a success story of medical oncology, germ cell cancer being regarded as the "model of a curable neoplasm". Even with metastatic disease, high cure rates can be achieved: the overall 5-year survival for all stages of TGCT is approximately 80%. Today, elaborate systems for prognostic evaluation for gonadal and extragonadal germ cell tumours facilitate the choice of the most appropriate therapy for individual patients. In doing so, the ultimate goal of treatment is tumour-free survival for any patient with TGCT. This goal has already been reached for >99% of the patients with early-stage tumours, as well as for the majority of patients with advanced disease (56% of patients with metastases are considered to have a good prognosis at the time of diagnosis; the 5-year survival rate for this group is 90%). However, patients with 'intermediate' or 'poor' prognosis at the time of diagnosis, as well as patients with relapsed disease after cisplatin-containing therapy, still have an unsatisfactorily low 5-year survival rate after standard therapy with PEB (cisplatin, etoposide, bleomycin) of only 80%, 45...Continue Reading

Citations

Dec 18, 2008·Human Genetics·Wasim K BleibelM Eileen Dolan
Aug 30, 2008·Nature Clinical Practice. Oncology·Giovanni PontiEmanuele Zucca
Jun 21, 2011·The Nurse Practitioner·Barbara H Zoltick
Mar 21, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·A Bergamo, G Sava
Aug 15, 2009·Journal of Cancer Research and Clinical Oncology·Johannes ClassenMichael Bamberg
Dec 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jörg T HartmannUNKNOWN German Testicular Cancer Study Group
Apr 7, 2017·Journal of Medical Imaging·Anna Leida MölderAnette Gjörloff-Wingren
Mar 15, 2019·PloS One·Michael T BarrettAlan H Bryce
Aug 29, 2020·Journal of Cellular and Molecular Medicine·Jingchao WeiYuxin Tang
May 24, 2018·Journal of Cancer Research and Clinical Oncology·Evangeline Armstrong-GordonNial J Wheate

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