PMID: 9553907Apr 29, 1998Paper

Advances in the understanding of malignant transformation of keratinocytes: an immunohistochemical study

Journal of the European Academy of Dermatology and Venereology : JEADV
M G TucciG Ricotti

Abstract

We set out to investigate the interactions between malignant transformation of keratinocytes, presence of oncoproteins and immunosurveillance in squamous cell carcinoma (SCC) and in a preneoplastic lesion, actinic keratosis (AK). Samples of SCC, AK and normal skin (NS) were subjected to quantitative analysis using the following antibodies: anti-p53, Ki67, OKT6, OK-DR, B7/BB1, anti-CD54, anti-CD11, OKT3, OKT4, OKT8; positivity for ras-p21, EGFr and bcl-2 was evaluated by semiquantitative analysis. Oncoprotein alterations and increased keratinocyte proliferative activity were observed both in AK and SCC. The number of Langerhans cells (CD1a+ cells) was similar in the two lesions but lower in SCC compared to AK. The proportion of CD1a(+)-B7/BB1+ cells was slightly higher in AK and SCC than in NS. The Langerhans cells expressed the HLA-DR antigen in all groups. Values were highest in AK and NS, and quite low in SCC. Cytotoxic T lymphocytes were more numerous in SCC than in AK and NS. Interestingly, the total CD4/CD8 ratio was much lower in SCC than in AK and NS, which indicates an increase in the CD8+ subpopulation in samples of SCC. In the epithelia of SCC samples there were a considerable number of B7/BB1+ keratinocytes. We sugge...Continue Reading

Citations

Feb 6, 2004·Journal of Dermatological Science·Andrija StanimirovićMladen Belicza
May 22, 2001·The British Journal of Dermatology·E StockflethE Christophers
Feb 24, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·U BartaU Wollina
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·D TomasM Belicza
Aug 22, 2006·Journal of Cutaneous Pathology·Dalva Regina Neto PimentelLuc Weckx
Feb 22, 2013·The Australasian Journal of Dermatology·Daniel C GaffneyFiona Simpson

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