Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours: part 1. Proliferation, apoptosis and DNA repair

The Veterinary Journal
A J F Matos, A A Santos

Abstract

There have been significant recent advances in the understanding of the molecular events and critical pathways associated with and driving cancer of the mammary gland in humans and dogs. The study of canine mammary tumour biology, particularly of the molecular events associated with proliferation, cell survival, invasion and metastasis, is crucial for the development of effective therapeutic agents and strategies. In this first part of a two-part review, recent advances in the understanding of the clinically relevant genetic and molecular pathways driving cell proliferation, apoptosis and DNA repair in canine mammary gland tumours are described.

References

Jul 31, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L L PeñaM Castaño
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Mar 14, 2000·Veterinary Pathology·Y FunakoshiK Doi
Aug 17, 2000·The Journal of Veterinary Medical Science·Y MurakamiR Yamaguchi
Nov 15, 2002·Molecular and Cellular Endocrinology·Evert van Garderen, Jack A Schalken
Mar 12, 2003·Veterinary Pathology·D J Argyle, L Nasir
Apr 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Giuseppe SarliPaolo Stefano Marcato
Sep 25, 2003·Breast Cancer Research and Treatment·J Martin de las MulasS Ramón y Cajal
Sep 24, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ramasamy KumaraguruparanSiddavaram Nagini
Jan 24, 2006·American Journal of Veterinary Research·Yutaka KanaeMasanobu Hayashi
Aug 23, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Serena PanareseGiuseppe Sarli
Feb 12, 2008·Domestic Animal Endocrinology·Elpetra P M Timmermans-SprangJan A Mol
May 8, 2008·Veterinary Research Communications·C W QiuG Z Deng
Jun 20, 2008·Journal of Veterinary Internal Medicine·D F MerloV Bocchini
Jul 16, 2008·Journal of Veterinary Internal Medicine·K Bundgaard-AndersenD Trerè
Oct 3, 2008·American Journal of Veterinary Research·Yasunaga YoshikawaToshihiko Iwanaga
Oct 7, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Katerina AngelopoulouIoannis Vlemmas
Mar 31, 2009·BMC Genomics·Paolo UvaEmanuele de Rinaldis
May 16, 2009·Current Cancer Drug Targets·Pepita Giménez-BonaféRicardo Pérez-Tomás
Jun 12, 2009·Journal of Comparative Pathology·R Klopfleisch, A D Gruber
Jul 28, 2009·Journal of Comparative Pathology·R KlopfleischA D Gruber
Aug 18, 2009·Journal of the American Veterinary Medical Association·Chao-Chin ChangShih-Chieh Chang
Sep 15, 2009·Research in Veterinary Science·R KlopfleischA D Gruber
Dec 1, 2009·The Veterinary Journal·Wei-Li HsuShih-Chieh Chang
Jan 19, 2010·Veterinary Pathology·R KlopfleischA D Gruber
Jan 30, 2010·BMC Veterinary Research·Francesco SassiGiuseppe Sarli
Apr 13, 2010·Research in Veterinary Science·Felisbina L QueirogaJuan C Illera

❮ Previous
Next ❯

Citations

Jun 28, 2016·Molecular BioSystems·F CecilianiC Lecchi
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Enni Markkanen
Aug 8, 2018·Veterinary Sciences·Liliana M E FinocchiaroGerardo C Glikin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.