Abstract
Imiquimod (IQ) is an immune-response modifying agent, first approved by FDA for the topical treatment of external genital and perianal warts in 1997. It induces, through stimulation of Toll-like receptors (TLRs) localized on the surface of antigen-presenting cells, synthesis and release of several endogenous pro-inflammatory cytokines such as interferon-alpha (IFN-alpha), tumor necrosis factor-alpha (TNF-alpha) and interleukins (IL) 6 and 12, which in turn stimulate both the innate and acquired immune pathways, resulting in upregulation of natural antiviral and antitumor activity. IQ 5% cream has been used for the treatment of a wide variety of dermatologic conditions in which the immune system is thought to play a role in regression of the disease. In some disorders, such as genital and perianal warts, actinic keratoses, basal cell carcinomas, Bowen's disease and molluscum contagiosum, relative safety and efficacy are supported by randomized controlled trials of IQ. However, it is common for patients to experience local skin reactions, which can range from mild to severe in intensity, but usually resolve 1-2 weeks after interrupting treatment. Additional randomized trials are encouraged to assess safety and efficacy of IQ in t...Continue Reading
Citations
Feb 15, 2011·Cancer Investigation·Simon ChangClaus Johansen
Jun 15, 2014·BMC Infectious Diseases·Wenfei LiWang Cao
Dec 4, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·E Stockfleth
Mar 10, 2016·The Australasian Journal of Dermatology·Kristyn Deen, David Burdon-Jones
Sep 16, 2017·Journal of Food and Drug Analysis·Yi-Hsing ChenYu-Kuo Chen
Mar 7, 2013·Nature Communications·Anne WalterMaries van den Broek
Nov 19, 2013·Expert Review of Anticancer Therapy·Giuseppe MicaliMaria Rita Nasca
Jul 17, 2015·Dermatologic Therapy·Zaouak AnissaFenniche Samy
Apr 19, 2019·Clinical Case Reports·Maiko YokoyamaKiyofumi Egawa
May 21, 2015·Journal of Materials Science. Materials in Medicine·Man MaNan Li
Feb 2, 2013·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Chunjun YangSen Yang
Oct 24, 2013·The Journal of Dermatology·Noriko TanakaTakashi Hashimoto
Apr 23, 2010·Expert Opinion on Pharmacotherapy·Giuseppe MicaliMaria Rita Nasca
Sep 7, 2020·International Journal of Pharmaceutics·Akmal H SabriMaria Marlow
Apr 10, 2010·The Journal of Hand Surgery·Hyun Sik GongGoo Hyun Baek