Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

International Journal of Molecular Sciences
Safia NazJinghua Chen

Abstract

Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

References

Feb 3, 2007·Journal of the American Chemical Society·Jean-Paul FortinFlorence Gazeau
May 6, 2010·Molecular Cancer Therapeutics·Issam Ben SahraFrédéric Bost
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arti HurriaWilliam P Tew
Jan 21, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Frederico PittellaKazunori Kataoka
Mar 19, 2014·Trends in Biotechnology·Tarek R Fadel, Tarek M Fahmy
May 30, 2014·Expert Opinion on Drug Delivery·Sophie LaurentMorteza Mahmoudi
Jul 6, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Min Sang LeeJi Hoon Jeong
Dec 3, 2014·Trends in Pharmacological Sciences·Cong LuoZhonggui He
Jan 18, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sudipta SenapatiPralay Maiti
Feb 16, 2016·Scientific Reports·Alexandra RodzinskiSakhrat Khizroev
Mar 2, 2016·Journal of Colloid and Interface Science·Li LiZhi Ping Xu
Apr 9, 2016·Colloids and Surfaces. B, Biointerfaces·Prashanth K B NageshMurali M Yallapu
Jul 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jenny Arratia-QuijadaGregorio Guadalupe Carbajal Arízaga
Nov 12, 2016·Nature Reviews. Cancer·Jinjun ShiOmid C Farokhzad
Feb 9, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shama DissanayakeVijayalekshmi Sarojini
Mar 21, 2017·Acta Pharmacologica Sinica·Y RajeshMahitosh Mandal
May 24, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sabina Quader, Kazunori Kataoka
Jun 26, 2017·Nanomedicine : Nanotechnology, Biology, and Medicine·Li LiZhi Ping Xu
Jul 10, 2017·Colloids and Surfaces. B, Biointerfaces·Feray BakanEmir Baki Denkbas
Aug 20, 2017·Journal of Molecular Graphics & Modelling·Mehrnoosh Khodam HazratiZargham Bagheri
Sep 1, 2017·Colloids and Surfaces. B, Biointerfaces·Min-Song LinLan-Sun Zheng
Oct 27, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Nagarani ThotakuraKaisar Raza
Nov 12, 2017·Acta Biomaterialia·Marina Martínez-CarmonaMaría Vallet-Regí
Nov 29, 2017·Biomaterials·Sheng-Hung Wang, John Yu
Jan 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Meng QiuYihai Cao
Jan 19, 2018·Scientific Reports·Tamoghna MandalChristian Buske

❮ Previous
Next ❯

Citations

Sep 27, 2019·Journal of Tissue Engineering·Rajendra K SinghHae-Won Kim
Dec 22, 2019·International Journal of Molecular Sciences·Buddhadev Layek, Jagdish Singh
Sep 8, 2019·International Journal of Molecular Sciences·Natalia SiweckaIreneusz Majsterek
Jun 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jinxia LiFeng Zhao
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Seyed Zachariah MoradiMohammad Abdollahi
May 8, 2020·Journal of Immunology Research·Manal Ali BuabeidGhulam Murtaza
Aug 9, 2020·Journal of Oncology·Randa ZeinKim Selting
Aug 15, 2020·Frontiers in Pharmacology·Priyanka SharmaMarco Tafani
Oct 29, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Charlene Andraos, Mary Gulumian
Mar 7, 2021·Nanomaterials·Anteneh Marelign BeyeneTaesun Min
Feb 13, 2021·Chemistry : a European Journal·Viktoriya Sokolova, Matthias Epple
Jan 27, 2022·ACS Biomaterials Science & Engineering·Yuan DengPeifu Tang

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence imaging
xenografts
transfection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.