Advances in Therapeutic Options for Gait and Balance in Parkinson's Disease

US Neurology
Nicolaas I BohnenKelvin Chou

Abstract

There is a need to explore non-dopaminergic approaches to treating balance and gait problems in PD. There is emerging evidence on the role of cholinergic denervation of the PPN-thalamus system and falls in PD. Preliminary clinical trial data suggest that the subgroup of PD patients with frequent falls may be suitable candidates for future cholinergic augmentation clinical trials. Recent controlled clinical trials using methylphenidate have been unable to confirm earlier reports of improved gait in PD. Although progressive deterioration of axial motor symptoms occur with DBS of the STN or GPi, new preliminary research suggests that other surgical stimulation sites, such as the PPN, may have a potential benefit on gait and balance impairments in PD. Ongoing vigorous exercise and physical fitness should be highly encouraged to patients with PD who are at risk of physical deconditioning and fear of falling but effective anti-fall physical therapy interventions remain an unmet clinical need.

Citations

Mar 5, 2016·Frontiers in Computational Neuroscience·Ahmed A MoustafaDorota Frydecka
Apr 18, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L ZhangH H Ye
Aug 25, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Samuel StuartMartina Mancini
Aug 24, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maryka QuikXiomara Perez

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