Advances in therapies and scope for personalized medicine in Alzheimer's disease

Personalized Medicine
Hosakere N RavishankarAmogh Mohan

Abstract

Alzheimer's disease is one of the leading causes of death worldwide and currently does not have any cure. The rate of incidence of Alzheimer's from 2010 is up by 71%, whereas many other diseases have been decreasing in their prevalence. In this review, we have attempted to cover the current landscape of treatment alongside forthcoming advances. We have also covered the present genes identified through genome-wide association studies, which could be used as novel biomarkers and could eventually reduce the cost of treatment through early diagnosis. As this disease is highly polymorphic, applications of personalized medicine have also found its way. All these upcoming developments offer a bright hope in the diagnosis and treatment of this disease.

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Aug 13, 1998·Journal of Neural Transmission. Supplementum·H Braak, E Braak
Jan 14, 2000·Archives of Neurology·S M GreenbergJ H Growdon
Feb 15, 2001·Dementia and Geriatric Cognitive Disorders·J AerssensW Parys
Mar 29, 2001·Physiological Reviews·D J Selkoe
Aug 15, 2001·Neurology·B WinbladUNKNOWN Donepezil Nordic Study Group
Aug 7, 2002·Clinical Pharmacokinetics·Michael W JannGary W Small
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Dennis J Selkoe, Dale Schenk
Nov 16, 2002·Science·M PfeiferM Jucker
Apr 4, 2003·The New England Journal of Medicine·Barry ReisbergUNKNOWN Memantine Study Group
Oct 29, 2005·Dementia and Geriatric Cognitive Disorders·Guk-Hee SuhUNKNOWN Korean Galantamine Study Group
Feb 1, 2006·The Pharmacogenomics Journal·M E RisnerUNKNOWN Rosiglitazone in Alzheimer's Disease Study Group
Feb 8, 2006·Archives of General Psychiatry·Margaret GatzNancy L Pedersen
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·James A R NicollClive Holmes
Nov 30, 2006·Alzheimer Disease and Associated Disorders·Rafael BlesaJose Félix Martí Massó
Feb 9, 2010·Nature Reviews. Neurology·Giovanni B FrisoniPaul M Thompson
May 13, 2010·JAMA : the Journal of the American Medical Association·Sudha SeshadriUNKNOWN EADI1 Consortium
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Sep 14, 2010·Disease-a-month : DM·Rudy J CastellaniMark A Smith
Oct 26, 2010·Trends in Biotechnology·Christian Humpel
Jan 29, 2011·Clinical Pharmacology and Therapeutics·M V Relling, T E Klein
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Feb 9, 2012·PloS One·Carlos CruchagaUNKNOWN NIA-LOAD/NCRAD Family Study Consortium
Mar 9, 2012·The New England Journal of Medicine·Robert HowardPatrick Phillips
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Keith A JohnsonWilliam E Klunk
Jul 27, 2012·Translational Psychiatry·M I KambohM M Barmada
Oct 2, 2012·Metabolism: Clinical and Experimental·Theodore B Vanitallie
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Feb 2, 2013·Clinical Pharmacokinetics·Muriel NoetzliChin B Eap
Jun 6, 2013·Journal of Neuroinflammation·David A Loeffler
Jul 26, 2013·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Semagacestat Study Group
Jan 8, 2014·Annual Review of Pharmacology and Toxicology·Karen Chiang, Edward H Koo
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
genotyping

Clinical Trials Mentioned

NCT00594568
NCT02322021
NCT01739348
NCT01953601

Software Mentioned

PharmGKB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved