PMID: 7940978Oct 1, 1994Paper

Advances in understanding cytomegalovirus infection after transplantation

Transplantation Proceedings
M Ho

Abstract

Susceptibility to infection and disease caused by CMV varies with the degree of immunosuppression, the antecedent immunity to CMV, the source of the virus, and a complex set of host responses. These responses include the development of humoral and cellular immunity and also immunopathologic responses. HLA-restricted responses may facilitate CMV disease by facilitating the survival and activation of latently infected cells, or by facilitating MHC-class I or class II cellular immune responses underlying both protective effects and pathologic inflammation.

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