Advances in understanding the pathophysiology of autism spectrum disorders

Behavioural Brain Research
Konstantin YenkoyanDiana Yepremyan

Abstract

Autism spectrum disorders (ASD) are common heterogeneous neurodevelopmental disorders with typical triad of symptoms: impaired social interaction, language and communication abnormalities and stereotypical behavior. Despite extensive research, the etiology and pathogenesis of ASD remain largely unclear. The lack of solid knowledge on the mechanisms of these disorders decreases the opportunities for pathogenetic treatment of autism. Various theories where proposed in order to explain the pathophysiology underlying ASD. Despite the fact that none of them is able to completely explain the impairments in the nervous system of ASD patients, these hypotheses were instrumental in highlighting the most important mechanisms in the development of this complex disorder. Some new theories are based on neurovisualization studies, others on the data from genomic studies, which become increasingly available worldwide. As the research in this field is largely dependent on the animal models, there is an ongoing discussion and search for the most appropriate one adequately reproducing the pathology. Here we provide an overview of current theories of the origin and development of ASD discussed in the context of existing and proposed rodent models...Continue Reading

Citations

Jan 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mary Ann RaghantiC Owen Lovejoy
Sep 24, 2020·PloS One·Karin MeissnerMatthias H Tschoep
Feb 26, 2019·Frontiers in Endocrinology·Tal Shomrat, Nir Nesher
Jul 8, 2020·International Journal of Molecular Sciences·Ann Genovese, Merlin G Butler
Aug 7, 2019·Autism Research : Official Journal of the International Society for Autism Research·Sérine BenachenhouArtuela Çaku
Sep 23, 2020·Journal of Medical Case Reports·Juliana Andrea PontonRobert Lawrence Tanguay
Jul 31, 2018·Brain : a Journal of Neurology·Joanna SzczurkowskaLaura Cancedda
Jun 23, 2019·Antioxidants·Joško OsredkarMaja Jekovec Vrhovšek
Jul 6, 2020·Neuroscience and Biobehavioral Reviews·Geir BjørklundSalvatore Chirumbolo
Jan 30, 2021·Frontiers in Behavioral Neuroscience·Angel Carvajal-Oliveros, Jorge M Campusano
Feb 23, 2021·Frontiers in Pharmacology·Cássio Morais LossVanessa Costhek Abílio
Feb 27, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Omyma G AhmedNessren M Abd El-Rady
Oct 11, 2021·BMC Neuroscience·Diego Alejandro Rodriguez-GomezClaudia Talero-Gutiérrez
Aug 19, 2020·Developmental Neuroscience·Devahuti ChalihaJohn Mamo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism: Treatment Targets

The absence of effective treatments for autism are due to the high clinical and genetic heterogeneity between affected individuals, restricted knowledge of the underlying pathophysiological mechanisms, and the lack of reliable diagnostic biomarkers. Identification of more homogenous biological subgroups is therefore essential for the development of novel treatments based on the molecular mechanisms underpinning autism and autism spectrum disorders. Find the latest research on autism treatment targets here.

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Frontiers in Neurology
Catherine A EdmonsonOwen M Rennert
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Sheryl S MoyJacqueline N Crawley
Biological Psychiatry
Carolyn M YrigollenElena L Grigorenko
© 2022 Meta ULC. All rights reserved