Advances in understanding the response of fish to linear alcohols in the environment

Chemosphere
S E BelangerRicky Stackhouse

Abstract

Short to long chain alcohols have a range of ecotoxicity to aquatic life driven by hydrophobic interactions with biological membranes. Carbon chain length and octanol:water partitioning coefficients are surrogates for hydrophobicity and strongly relate to aquatic toxicity. In these investigations, the toxicity of ethanol to 1-n-dodecanol to juvenile fish in standard acute toxicity tests is reviewed. Toxicity tests employing fish embryos (zebrafish Danio rerio and fathead minnow Pimephales promelas) in the Fish Embryo Test (OECD 236) format were conducted from C2 to C10 to compare against standard juvenile fish toxicity. Quantitative structure activity relationships for FET and fish individually and combined demonstrate that embryos are not different in sensitivity to juvenile fish. A combined QSAR was developed of the form Log 96 h LC50 (mM/L) = -0.925*log Kow + 2.060 (R2 10 = 0.954). Alcohols of 11-12 carbons show a deflection in the QSAR as toxicity approaches the solubility limit. Alcohols with longer chain lengths may only be tested at lower exposures relevant for chronic toxicity. Decanol was evaluated in a 33-d fish early life stage test (OECD 210) and survival was the most sensitive endpoint (EC10 = 0.43 mg/L, 0.0027 mM/...Continue Reading

References

Jan 10, 2004·Environmental Toxicology and Chemistry·Thomas H HutchinsonRoy S Thompson
Jul 20, 2005·Ecotoxicology and Environmental Safety·Thomas W Federle, Nina R Itrich
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May 25, 2006·Environmental Science & Technology·Scott D DyerFoster L Mayer
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Apr 23, 2013·Environmental Toxicology and Chemistry·Scott E BelangerGregory J Carr
Nov 10, 2013·The Science of the Total Environment·Stephen M MudgeScott D Dyer
Oct 5, 2016·Environmental Toxicology and Chemistry·Scott GlabermanMace G Barron
Aug 2, 2017·Environmental Science & Technology·A KienzlerM R Embry

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Citations

Jan 10, 2020·Environmental Science and Pollution Research International·Shengnan ZhangYuanhui Zhao
Jul 31, 2021·The Science of the Total Environment·Laura M Saavedra, Pablo R Duchowicz

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