Applications of proteomics tools revolutionized various biomedical disciplines such as genetics, molecular biology, medicine, and dentistry. The aim of this review is to highlight the major milestones in proteomics in dentistry during the last fifteen years. Human oral cavity contains hard and soft tissues and various biofluids including saliva and crevicular fluid. Proteomics has brought revolution in dentistry by helping in the early diagnosis of various diseases identified by the detection of numerous biomarkers present in the oral fluids. This paper covers the role of proteomics tools for the analysis of oral tissues. In addition, dental materials proteomics and their future directions are discussed.
Efficient detection of three-dimensional structural motifs in biological macromolecules by computer vision techniques
Cathepsins B, H and L activities in gingival crevicular fluid from chronic adult periodontitis patients and experimental gingivitis subjects
Calbindin28kDa and calmodulin are hyperabundant in rat dental enamel cells. Identification of the protein phosphatase calcineurin as a principal calmodulin target and of a secretion-related role for calbindin28kDa
Abundant calcium homeostasis machinery in rat dental enamel cells. Up-regulation of calcium store proteins during enamel mineralization implicates the endoplasmic reticulum in calcium transcytosis
Isolation of ERp29, a novel endoplasmic reticulum protein, from rat enamel cells. Evidence for a unique role in secretory-protein synthesis
Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo
Proteomic analysis of human skin fibroblasts grown on titanium: novel approach to study molecular biocompatibility
Amino acid-base interactions: a three-dimensional analysis of protein-DNA interactions at an atomic level
Analysis of gene and protein expression in healthy and carious tooth pulp with cDNA microarray and two-dimensional gel electrophoresis
Amelogenin supra-molecular assembly in vitro compared with the architecture of the forming enamel matrix
Proteomic analysis of the saliva: a clue for understanding primary from secondary Sjögren's syndrome?
Bioinformatic analysis and molecular modelling of human ameloblastin suggest a two-domain intrinsically unstructured calcium-binding protein
Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis
Differentially expressed protein profile of human dental pulp cells in the early process of odontoblast-like differentiation in vitro
Quantification of monomer elution and carbon-carbon double bonds in dental adhesive systems using HPLC and micro-Raman spectroscopy
Early osteogenic differential protein profile detected by proteomic analysis in human periodontal ligament cells
Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects
Understanding the mechanical behaviour of human enamel from its structural and compositional characteristics
Identification of proteinaceous inhibitors of a cysteine proteinase (an Arg-specific gingipain) from Porphyromonas gingivalis in rice grain, using targeted-proteomics approaches
Discovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancer
A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures
Proteome data set of human gingival crevicular fluid from healthy periodontium sites by multidimensional protein separation and mass spectrometry
Novel protein identification methods for biomarker discovery via a proteomic analysis of periodontally healthy and diseased gingival crevicular fluid samples
Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes
Quantitative proteomic analysis of human osteoblast-like MG-63 cells in response to bioinert implant material titanium and polyetheretherketone
Identification of a protein-containing enamel matrix layer which bridges with the dentine-enamel junction of adult human teeth
Mass spectrometric analysis of gingival crevicular fluid biomarkers can predict periodontal disease progression
Investigation and identification of potential biomarkers in human saliva for the early diagnosis of oral squamous cell carcinoma
Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometry
The Human Dental Pulp Proteome and N-Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues
Applications of Light Amplification by Stimulated Emission of Radiation (Lasers) for Restorative Dentistry
Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection
The Impact of Hyposalivation on Quality of Life (QoL) and Oral Health in the Aging Population of Al Madinah Al Munawarrah
Marginal bone loss around non-submerged implants is associated with salivary microbiome during bone healing
Assessing a multiplex-targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples
The importance of basic and engineering sciences for next generation research in the field of oral and maxillofacial surgery
Three-Dimensional Bone Substitutes for Oral and Maxillofacial Surgery: Biological and Structural Characterization
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