Advances of systemic treatment for adult soft-tissue sarcoma

Chinese Clinical Oncology
Wenshuai LiuYuhong Zhou

Abstract

Soft-tissue sarcoma (STS) is a group of rare but highly heterogeneous neoplasms. Systemic treatment with cytotoxic chemotherapy and targeted agents is one of the main therapeutic modalities in patients with unresectable or metastatic disease, while adjuvant and neoadjuvant chemotherapy for adult-type sarcomas remain controversial. Although an anthracycline (doxorubicin) and ifosfamide remain the cornerstone for chemotherapy, advances have been made recently to exceed its limited efficacy, other agents such as trabectedin, eribulin have been approved. In a recent study, the addition of platelet-derived growth factor receptor (PDGFR) antibody-olaratumab to doxorubicin resulted in prolongation of progression-free survival and overall survival, which really means a breakthrough for STS. There is more emerging evidence of different sensitivity to treatment for different histological subtypes, second-line treatment for advanced sarcoma is being increasingly driven by histology. Cytotoxic drugs such as dacarbazine, gemcitabine, and taxanes have shown moderate activity in specific subtypes. Tyrosine kinase inhibitors (TKIs), including pazopanib and anlotinib, appear to be the promising targeted therapies. Other signal pathway inhibitor...Continue Reading

Citations

Oct 9, 2020·Cancers·Caroline MolinaroKatia Cailliau
May 24, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Melissa E BarnesPaul F Ridgway
Jul 4, 2021·BMJ Case Reports·Viviana Marcela Hidalgo MoraCarlos Edgar Figueroa Avendaño
Aug 8, 2021·International Journal of Environmental Research and Public Health·Jakub PawlikAneta Cymbaluk-Płoska

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