Advances on a Decision Analytic Approach to Exposure-Based Chemical Prioritization

Risk Analysis : an Official Publication of the Society for Risk Analysis
Matthew D WoodD A Vallero

Abstract

The volume and variety of manufactured chemicals is increasing, although little is known about the risks associated with the frequency and extent of human exposure to most chemicals. The EPA and the recent signing of the Lautenberg Act have both signaled the need for high-throughput methods to characterize and screen chemicals based on exposure potential, such that more comprehensive toxicity research can be informed. Prior work of Mitchell et al. using multicriteria decision analysis tools to prioritize chemicals for further research is enhanced here, resulting in a high-level chemical prioritization tool for risk-based screening. Reliable exposure information is a key gap in currently available engineering analytics to support predictive environmental and health risk assessments. An elicitation with 32 experts informed relative prioritization of risks from chemical properties and human use factors, and the values for each chemical associated with each metric were approximated with data from EPA's CP_CAT database. Three different versions of the model were evaluated using distinct weight profiles, resulting in three different ranked chemical prioritizations with only a small degree of variation across weight profiles. Future w...Continue Reading

References

Feb 24, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·I LinkovA Meyer
Apr 28, 2006·Integrated Environmental Assessment and Management·Gregory A KikerIgor Linkov
Nov 23, 2011·The Science of the Total Environment·Peter P EgeghyElaine A Cohen Hubal
May 11, 2012·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matthew WoodIgor Linkov
May 28, 2013·The Science of the Total Environment·Jade MitchellDaniel A Vallero
Aug 14, 2013·PloS One·Jade MitchellDaniel A Vallero
Jun 17, 2016·Environmental Science & Technology·Timothy MalloyIgor Linkov
Jul 2, 2016·Chemical Research in Toxicology·Ann M RichardRussell S Thomas
Jul 4, 2017·Environmental Health Perspectives·Timothy F MalloyKristina A Thayer
Aug 5, 2017·Nature Nanotechnology·Igor LinkovJeffrey M Keisler
Jan 2, 2015·Toxicology Reports·Kathie L DionisioRichard S Judson

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Citations

Apr 30, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A KalkowskaKimberly M Thompson
Apr 30, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A Kalkowska, Kimberly M Thompson
Aug 21, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Vicki Bier
Dec 16, 2020·Environmental Science & Technology·Clara M A EichlerJohn C Little
Jul 17, 2020·Chemical Research in Toxicology·Gabriele SabbioniBilly W Day

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