Advances on the Determination of the Astatine Pourbaix Diagram: Predomination of AtO(OH)2 (-) over At(-) in Basic Conditions

Chemistry : a European Journal
Dumitru-Claudiu SergentuGilles Montavon

Abstract

It is generally assumed that astatide (At(-) ) is the predominant astatine species in basic aqueous media. This assumption is questioned in non-complexing and non-reductive aqueous solutions by means of high-pressure anion-exchange chromatography. Contrary to what is usually believed, astatide is found to be a minor species at pH=11. A different species, which also bears a single negative charge, becomes predominant when the pH is increased beyond 7. Using competition experiments, an equilibrium constant value of 10(-6.9) has been determined for the formation of this species from AtO(OH) with the exchange of one proton. The identification of this species, AtO(OH)2 (-) , is achieved through relativistic quantum mechanical calculations, which rule out the significant formation of the AtO2 (-) species, while leading to a hydrolysis constant of AtO(OH) in excellent agreement with experiment when the AtO(OH)2 (-) species is considered. Beyond the completion of the Pourbaix diagram of astatine, this new information is of interest for the development of (211) At radiolabeling protocols.

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Citations

Apr 12, 2016·European Journal of Medicinal Chemistry·Tahra AyedNicolas Galland
Apr 10, 2016·Journal of Computational Chemistry·Dumitru-Claudiu SergentuNicolas Galland
Mar 21, 2018·Nature Chemistry·Ning GuoNicolas Galland
Nov 15, 2016·Physical Chemistry Chemical Physics : PCCP·Dumitru-Claudiu SergentuRémi Maurice
Oct 29, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Geerd-J Meyer
Jun 16, 2016·Chemistry : a European Journal·François GuérardMartin W Brechbiel
Oct 2, 2017·Bioorganic & Medicinal Chemistry·F GuérardJ-F Gestin
Jun 15, 2021·Organic & Biomolecular Chemistry·Keitaro MatsuokaShigeki Matsunaga
Jun 19, 2021·Biotechnology and Bioengineering·Timothy BrantleySarwat Khattak
Jul 3, 2021·Pharmaceutics·Romain EychenneJean-François Gestin
Aug 6, 2021·Accounts of Chemical Research·François GuérardNicolas Galland
Aug 28, 2021·Chemical Science·Lu LiuNicolas Galland

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