PMID: 11934597Apr 6, 2002Paper

Advances towards understanding heart valve response to injury

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Adam Durbin, Avrum I Gotlieb

Abstract

Composed of endocardial endothelial, valvular interstitial, cardiac muscle, and smooth muscle cells (SMC), heart valves are prone to various pathologic conditions the morphology of which has been well described. The morphology of diseased valves suggest that the "response to injury" process occurs in these valves, and is associated with an accumulation of interstitial cells and matrix, valvular inflammation and calcification, conditions that lead to dysfunction. The purpose of this study is to describe the current knowledge of the regulation of the valvular "response to injury" process, since we feel that this paradigm is essential to understanding valve disease. The pertinent literature relating to the cell and molecular biology of valvular repair, and specifically interstitial cell function in valve repair, is reviewed. The cell and molecular biology of valve interstitial cells are poorly understood. Molecules regulating some of the aspects of the "response to injury" process have been studied, however, the signal transduction pathways, gene activation, and interactions of bioactive molecules with each other, with cells, and with the matrix have not been characterized. Initial studies identify the cell and molecular biology o...Continue Reading

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Citations

Sep 6, 2011·Journal of Cardiovascular Translational Research·Kareem SalhiyyahAdrian H Chester
Feb 16, 2005·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Adam DurbinAvrum I Gotlieb
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