Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia.

Journal of Applied Physiology
Conwin K VanterpoolJ N Buchholz

Abstract

Sympathetic nerves arising from the superior cervical ganglion (SCG) protect the cerebrovasculature during periods of acute hypertension and may play a role in homeostasis of target organs. The functions of these nerves depend on calcium release triggered by activation of ryanodine receptor (RyR) channels. The function of RyR channels is in part dependent on genetic expression and regulation by numerous protein modulators such as neuronal nitric oxide synthase (nNOS) neurons also found in the SCG. We have shown that release of calcium in SCG cells is altered during late maturation and advancing age. However, the underlying molecular mechanisms that may in part account for these data are elusive. Therefore we used molecular techniques to test the hypothesis that advancing age alters the pattern of genetic expression and/or protein levels of RyRs and their modulation by nNOS in the SCG in F344 rats aged 6, 12, and 24 mo. Surprisingly, ryr1 expression was undetectable in all age groups and ryr2 and ryr3 are the predominantly transcribed isoforms in the adult rat SCG. mRNA and protein levels for RyR2 isoform did not change with advancing age. However, ryr3 mRNA levels increased from 6 to 12 mo and declined from 12 to 24 mo. Similar...Continue Reading

References

Dec 1, 1990·The Journal of Experimental Medicine·K RamaswamyD Befus
Oct 1, 1988·Trends in Neurosciences·M Fill, R Coronado
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C E Hill, M Vidovic
Sep 1, 1986·Journal of the Autonomic Nervous System·H E RomeoD P Cardinali
Jan 1, 1984·Reviews of Physiology, Biochemistry and Pharmacology·D W Busija, D D Heistad
Jan 1, 1981·Journal of Neural Transmission·D P CardinaliP V Gejman
Jan 1, 1995·Advances in Pharmacology·V Sorrentino
Jan 1, 1994·Biological Signals·J E Stern, D P Cardinali
Feb 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·M JallageasA Lacroix
Jan 15, 1993·Science·A Galione
Nov 1, 1996·Neurobiology of Aging·J BuchholzS P Duckles
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Apr 16, 1998·The Journal of Biological Chemistry·D A FerringtonD J Bigelow
Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Y M Usachev, S A Thayer
Sep 1, 1999·Microscopy Research and Technique·P J Larsen
Nov 26, 1999·Life Sciences·L Van Den BoschW Robberecht
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T J LeeS Sarwinski
Dec 13, 2000·Experimental Gerontology·G J Brewer
Jan 11, 2001·Trends in Cardiovascular Medicine·Y OgawaT Murayama
Mar 7, 2001·Biochemical Pharmacology·J P EuG Meissner
Mar 10, 2001·Antioxidants & Redox Signaling·I N Pessah, W Feng
Mar 10, 2001·Antioxidants & Redox Signaling·K AnzaiH Yamamoto
Mar 10, 2001·Antioxidants & Redox Signaling·S L Hamilton, M B Reid
May 15, 2001·Journal of Autonomic Pharmacology·W J PottorfJ N Buchholz
Nov 24, 2001·Mechanisms of Ageing and Development·Nektarios Tavernarakis, Monica Driscoll
Mar 14, 2002·The Journal of Membrane Biology·D M BalshawG Meissner
Sep 25, 2002·Physiological Reviews·Michael Fill, Julio A Copello
Nov 16, 2002·Journal of Applied Physiology·Emmanuel M MbakuJohn Buchholz

❮ Previous
Next ❯

Citations

Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erik J BehringerJohn N Buchholz
Aug 1, 2009·Journal of Applied Physiology·Erik J BehringerJohn N Buchholz
Nov 26, 2009·Pharmacology & Therapeutics·Isaac N PessahPamela J Lein
May 12, 2009·Ageing Research Reviews·Monika Puzianowska-Kuznicka, Jacek Kuznicki
Sep 20, 2011·Anatomia, histologia, embryologia·B P ShaoJ L Wang
Jul 31, 2007·Biochemical Pharmacology·Pedro J Gomez-PinillaPedro J Camello
Oct 20, 2006·The Journal of Biological Chemistry·Charlene SupnetMichael Mayne
Jan 30, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Erika M Boerman, Steven S Segal
Jan 20, 2017·Molecular Neurobiology·Nawaf Abu-OmarZhong-Ping Feng
Jul 6, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Michiko JoJerome W Breslin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.