Jan 25, 2018

Advancing biotechnology with CRISPR/Cas9: recent applications and patent landscape

Journal of Industrial Microbiology & Biotechnology
Raphael FerreiraJens Nielsen

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR) is poised to become one of the key scientific discoveries of the twenty-first century. Originating from prokaryotic and archaeal immune systems to counter phage invasions, CRISPR-based applications have been tailored for manipulating a broad range of living organisms. From the different elucidated types of CRISPR mechanisms, the type II system adapted from Streptococcus pyogenes has been the most exploited as a tool for genome engineering and gene regulation. In this review, we describe the different applications of CRISPR/Cas9 technology in the industrial biotechnology field. Next, we detail the current status of the patent landscape, highlighting its exploitation through different companies, and conclude with future perspectives of this technology.

  • References99
  • Citations2

Citations

Mentioned in this Paper

Immune System
CRISPR-Cas Systems
Bacteriophages
Streptococcus pyogenes
Organism
Biotechnology
Clustered Regularly Interspaced Short Palindromic Repeats
Statistical Technique
Manipulating Function
Type 2

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