Advancing insights into stem cell niche complexities with next-generation technologies

Current Opinion in Cell Biology
Nicholas HeitmanMichael Rendl

Abstract

Adult tissue-specific stem cells are essential for homeostatic tissue maintenance and key to regeneration during injury repair or disease. Many critical stem cell functions rely on the presence of well-timed cues from the microenvironment or niche, which includes a diverse range of components, including neuronal, circulating and extracellular matrix inputs as well as an array of neighboring niche cells directly interacting with the stem cells. However, studies of stem cells and their niche have been challenging due to the complexity of adult stem cell functions, their intrinsic controls and the multiple regulatory niche components. Here, we review recent major advances in our understanding of the complex interplay between stem cells and their niche that were enabled by the tremendous technological leaps in single-cell transcriptome analyses, 3D in vitro cultures and 4D in vivo microscopy of stem cell niches.

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Citations

Jun 28, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Dimitrios Tsiapalis, Dimitrios I Zeugolis
Nov 8, 2018·International Journal of Molecular Sciences·Chiara ArgentatiSabata Martino
Oct 3, 2020·Experimental Dermatology·Pieter A MartinoMichael Rendl
Nov 11, 2020·Biochemical Society Transactions·Maneesha Aruketty, Svitlana Kurinna
Jan 29, 2021·Experimental Dermatology·Jiyoon Lee, Karl R Koehler
Apr 2, 2021·Experimental Dermatology·Ya-Chieh Hsu, Michael Rendl
Jun 11, 2021·Nature·Nivedita Saxena, Michael Rendl
Oct 13, 2021·Cell Communication and Signaling : CCS·Xiangdong XuYiquan Ke

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