Advancing the delivery of anticancer drugs: Conjugated polymer/triterpenoid composite

Acta Biomaterialia
Katarzyna KrukiewiczBarbara Bednarczyk-Cwynar

Abstract

Exemplifying the synergy of anticancer properties of triterpenoids and ion retention qualities of conjugated polymers, we propose a conducting matrix to be a reservoir of anticancer compounds. In this study, poly(3,4-ethylenedioxythiophene), PEDOT, based matrix for electrically triggered and local delivery of the ionic form of anticancer drug, oleanolic acid (HOL), has been investigated. An initial, one-step fabrication procedure has been proposed, providing layers exhibiting good drug release properties and biological activity. Investigation of obtained systems and implementation of modifications revealed another route of fabrication. This procedure was found to yield layers possessing a significantly greater storage capacity of OL(-), as evidenced by the 52% increase in the drug concentrations attainable through electro-assisted release. Examination of the biological activity of immobilised and released OL(-) molecules proved that electrochemical treatment has negligible impact on the anticancer properties of OL(-), particularly when employing the three-step procedure, in which the range of applied potentials is limited. PEDOT/OL(-) composite has been demonstrated to be a robust and cost-effective material for controlled drug...Continue Reading

References

Jul 9, 1999·Journal of Biomedical Materials Research·B PiroT Ledoan
Jul 7, 1997·Advanced Drug Delivery Reviews·W M Saltzman, L K Fung
Jun 24, 2000·Planta medica·H Q TangR X Tan
Jan 24, 2002·The Journal of Pharmacy and Pharmacology·H IsmailiR Aquino
Jul 13, 2006·Mutation Research·Zdenka OvesnáDarina Slamenová
Nov 21, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Giuseppe CuriglianoRashmi Shah
Oct 7, 2008·Journal of Ethnopharmacology·Stéphane FontanayRaphaël Emmanuel Duval
Oct 17, 2009·Expert Opinion on Drug Delivery·Michiya Matsusaki, Mitsuru Akashi
Dec 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sheng-lei YanMei-chin Yin
Feb 10, 2010·Journal of Materials Science. Materials in Medicine·Lucas LeprinceSophie Demoustier-Champagne
Apr 3, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Darren SvirskisSanjay Garg
Sep 6, 2011·Colloids and Surfaces. B, Biointerfaces·Bishnu Prasad BastakotiKenichi Nakashima
Jan 10, 2012·Organic & Biomolecular Chemistry·Barbara Bednarczyk-CwynarBogusław Hładoń
Feb 6, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dorna EsrafilzadehGordon G Wallace
Feb 26, 2013·Bioorganic & Medicinal Chemistry Letters·Jia HaoHongbin Sun
Nov 16, 2013·Molecular Pharmaceutics·Yuanyuan GuoZhiping Zhang
Feb 22, 2014·Acta Biomaterialia·Richard BalintSarah H Cartmell
Jun 26, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Wen GaoYoungnam Cho

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Citations

Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Katarzyna Krukiewicz, Jerzy K Zak
Feb 16, 2017·Advanced Healthcare Materials·Josef GodingRylie Green
Mar 13, 2019·Advanced Materials·Erica ZeglioAnna Herland
Aug 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tomasz JaroszAgnieszka Stolarczyk
Jul 29, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna Puiggalí-JouCarlos Alemán
Sep 29, 2020·Advanced Drug Delivery Reviews·Dinorath Olvera, Michael G Monaghan
Sep 3, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahima BansalDarren Svirskis
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Dominika Czerwińska-GłówkaKatarzyna Krukiewicz
Sep 5, 2020·ACS Applied Materials & Interfaces·Arghya K BishalChristos G Takoudis

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