Advantageous effects of dexmedetomidine on haemodynamic and recovery responses during extubation for intracranial surgery

European Journal of Anaesthesiology
G TuranG Yuksel

Abstract

The anaesthetic method for intracranial neurosurgery must provide haemodynamic stability on emergence and allow early evaluation of the neurological status. In this study, we examined the effects of the alpha-2 agonist dexmedetomidine given at the end of the procedure to prevent hyperdynamic responses during extubation and to allow a comfortable and high-quality recovery. Forty ASA I-III patients, aged between 18 and 75 yr, having elective intracranial surgery, were divided into two random groups. Standard procedures and drugs were used for monitoring, induction and maintenance. Isoflurane was reduced by 50% 5 min before the end of the surgery, and in Group I dexmedetomidine 0.5 microg kg(-1) and in Group II 20 mL of 0.9% NaCl were administrated intravenously over 60 s. Systolic, diastolic and mean arterial pressures, and heart rate were recorded before intravenous administration and also at 1, 3 and 5 min after administration, 1 min before extubation, during extubation, 1, 3, 5, 10, 15, 20 and 30 min after extubation. Duration of extubation and recovery were noted, and the quality of extubation was evaluated on a 5-point scale. Mean arterial pressure and heart rate were significantly higher in Group II than in Group I (P < 0.0...Continue Reading

References

Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K NishinaH Obara
Jun 11, 2004·Journal of Intensive Care Medicine·Eike MartinS T John Sum-Ping
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·G GulerA Boyaci

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Citations

Jul 19, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Sebastian Giuseppe Russo, Anselm Bräuer
Apr 14, 2015·Anesthesiology and Pain Medicine·Sohan Lal Solanki, Vipin Kumar Goyal
Sep 12, 2018·International Anesthesiology Clinics·Sreekanth CherukuIsaac P Lynch
Mar 26, 2015·American Journal of Therapeutics·Rudrashish HaldarPrabhat K Singh
Jan 30, 2021·Anesthesiology Research and Practice·Tiffany H WongApolonia E Abramowicz

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