Advantages and Disadvantages of Combined Chemotherapy with Carmustine Wafer and Bevacizumab in Patients with Newly Diagnosed Glioblastoma: A Single-Institutional Experience

World Neurosurgery
Yukinori AkiyamaNobuhiro Mikuni

Abstract

To retrospectively determine the safety and efficacy of combined chemotherapy with carmustine (BCNU) wafer, bevacizumab, and temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma (GBM). A total of 54 consecutive newly diagnosed GBMs were resected at our institution between 2010 and 2016. Twenty-nine patients underwent BCNU wafer implantation into the resection cavity followed by standard radiochemotherapy with temozolomide (TMZ, Stupp regimen) plus additional bevacizumab treatment between 2013 and 2016. Twenty-five patients who underwent resection without BCNU implantation between 2010 and 2012 were enrolled as a control group; these patients were treated with the Stupp regimen and did not receive bevacizumab. This retrospective study included evaluation of progression-free survival and overall survival, plus comparisons between the combined therapy group and the control group. There were no significant differences in age, sex, Karnofsky Performance Status on admission, isocitrate dehydrogenase 1/2 mutation ratio, or resection rate between the combined and standard therapy groups. The median overall survival in the combined therapy group and control group was 24.2 months and 15.30, respectively (P = 0.027...Continue Reading

Citations

Dec 5, 2019·Anais Da Academia Brasileira De Ciências·Juliana M SoaresLuciana F Romão
Feb 1, 2019·Chinese Neurosurgical Journal·Lei WangYan Michael Li
Dec 5, 2020·Advanced Healthcare Materials·Fatemeh PoustchiMohammad-Ali Shahbazi
May 1, 2021·Cancers·Elisabete Cruz Da SilvaLaurence Choulier

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