Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles

Frontiers in Pharmacology
Lauren ArmsSusan Hua

Abstract

Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles) encapsulating therapeutic and/or imaging compounds that are used for the prevention, diagnosis and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. Nanomedicine technology aims to improve the balance between the efficacy and the toxicity of therapeutic compounds. Nanoparticles, one of the key technologies of nanomedicine, can exhibit a combination of physical, chemical and biological characteristics that determine their in vivo behavior. A key component in the translational assessment of nanomedicines is determining the biodistribution of the nanoparticles following in vivo administration in animals and humans. There are a range of techniques available for evaluating nanoparticle biodistribution, including histology, electron microscopy, liquid scintillation counting (LSC), indirectly measuring drug concentrations, in vivo optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine imaging. Each technique has its own advantages and limitations, as well as capabilities for assessing real-ti...Continue Reading

References

Jan 1, 1992·Magnetic Resonance Imaging·C B WiegersA E Martell
Apr 1, 1989·Radiology·C TilcockP MacDougall
Apr 1, 1989·Radiology·E C UngerC Tilcock
Oct 1, 1995·Regulatory Toxicology and Pharmacology : RTP·A ShigematsuT Satoh
Sep 2, 1998·European Radiology·P Reimer, B Tombach
Mar 19, 2002·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Jul 27, 2002·Science·Michael J O'ConnellRichard E Smalley
Mar 12, 2003·Genes & Development·Tarik F Massoud, Sanjiv S Gambhir
Jun 26, 2003·Journal of the American Chemical Society·Jie ZhengRobert M Dickson
Mar 5, 2004·Journal of Medicinal Chemistry·C Andrew BoswellCarolyn J Anderson
Jul 28, 2005·Journal of the American Chemical Society·Marie-Sophie MartinaSylviane Lesieur
Dec 8, 2005·Nature Biotechnology·Cameron C LeeFrancis C Szoka
Sep 22, 2006·Cellular Oncology : the Official Journal of the International Society for Cellular Oncology·V KooK Williamson
May 17, 2007·Anti-cancer Agents in Medicinal Chemistry·Gustav J StrijkersKlaas Nicolay
Sep 20, 2007·PloS One·Michael R McDevittDavid A Scheinberg
Nov 21, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·R R MercerV Castranova
Jan 25, 2008·Nano Letters·Keith B HartmanLon J Wilson
Jan 26, 2008·Journal of the American Chemical Society·Kathryn M L TaylorWenbin Lin
Jun 19, 2008·Advanced Drug Delivery Reviews·Conroy SunMiqin Zhang
Sep 12, 2008·Nanomedicine : Nanotechnology, Biology, and Medicine·Don B ElrodJodie L Conyers
Oct 23, 2008·Nano Letters·David P CormodeWillem J M Mulder
Oct 29, 2008·Chembiochem : a European Journal of Chemical Biology·Ji-Ae ParkYongmin Chang
Jan 13, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Terry M MayhewMatthias Ochs
Nov 17, 2009·ACS Nano·Angana SenpanGregory M Lanza
Jan 5, 2010·Bioorganic & Medicinal Chemistry Letters·Yuanqing ZhangYu-Mei Shen

❮ Previous
Next ❯

Citations

Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Jan 17, 2020·Materials·Anita StarońMarcin Banach
Apr 22, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Prashant DograZhihui Wang
Dec 16, 2020·Emerging Topics in Life Sciences·Parasuraman PadmanabhanBalázs Gulyás
Jan 23, 2021·PloS One·Agatha M ReigotoClaudia Mermelstein
Apr 21, 2021·Free Radical Research·Monalisa Mishra, Mrutyunjaya Panda
May 25, 2021·Bioengineering & Translational Medicine·Nikša RokiSilvia Muro
Aug 24, 2021·Nanoscale Research Letters·Suraiya Saleem, Rajaretinam Rajesh Kannan
Nov 25, 2021·Nanomedicine·Samuel BonnetSamuel Legeay

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence microscopy
light microscopy
transmission
scanning electron microscopy
X-ray
transmission electron microscopy
electron microscopy
fluorescence imaging
light scattering
imaging technique

Software Mentioned

STEM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Nanomedicine
Jaehong Key, James F Leary
Accounts of Chemical Research
Twan LammersFabian Kiessling
The International Journal of Applied Radiation and Isotopes
D Butterfield, R J McDonald
© 2022 Meta ULC. All rights reserved