Advantages of an annual single dose of ivermectin 400 micrograms/kg plus diethylcarbamazine for community treatment of bancroftian filariasis

Transactions of the Royal Society of Tropical Medicine and Hygiene
J P Moulia-PelatL Nicolas

Abstract

In 1994 and 1995, 2 supervised single dose treatments for bancroftian filariasis were given to all inhabitants ( > 3500) aged > or = 3 years on a Polynesian island. This island is divided into 4 political zones. Each zone was treated with a different dosage of the combination ivermectin (IVR) and diethylcarbamazine (DEC) as follows: (1) IVR 400 micrograms/kg plus DEC 6mg/kg, (2) IVR 400 micrograms/kg alone, (3) DEC 6 mg/kg alone (4) IVR 400 micrograms/kg plus DEC 3 mg/kg. 1717 inhabitants (aged > or = 20 years) had venous blood sampled when treated. The reductions in microfilaraemia prevalence rates one year after treatment were, respectively, 32%, 11%, 14% and 32%. The reductions in microfilaraemia levels one year after treatment were, respectively, 96%, 80%, 82% and 95%. Stool specimens from 82 children aged 6 years were examined for intestinal nematodes just before and just after treatment. IVR 400 micrograms/kg significantly reduced the prevalence and intensity of trichiuriasis. The combination IVR + DEC is a powerful tool for the control of lymphatic filariasis. Further studies are required to determine the appropriate presentation of DEC (salt and/or tablets), the frequency of treatment, and the duration of the control pr...Continue Reading

References

Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·M SabryM E Kilpatrick
Apr 19, 1990·The New England Journal of Medicine·E A OttesenS P Tripathy
Jun 3, 1988·JAMA : the Journal of the American Medical Association·V KumaraswamiS P Tripathy
Jun 1, 1994·The American Journal of Tropical Medicine and Hygiene·H Gelband
Jan 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·J P Moulia-PelatJ L Cartel
Jan 1, 1993·Medicinal Research Reviews·W C Campbell

❮ Previous
Next ❯

Citations

Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·L NicolasD R Mercer
Apr 1, 1996·The American Journal of Tropical Medicine and Hygiene·M ZhongS A Williams
Oct 9, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·G DreyerJ Norões
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W Meyrowitsch, P E Simonsen
Nov 8, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·K Na-BangchangJ Lazdins
Jun 22, 2002·International Journal for Parasitology·Wayne D Melrose
Jan 5, 2002·The Journal of Obstetrics and Gynaecology Research·S SethiD Kumar
Aug 26, 1999·Parasitology Today·E A OttesenJ Horton
Jun 25, 1999·Revista Da Sociedade Brasileira De Medicina Tropical·A R SeimD G Addiss
Feb 22, 2018·Archives of Disease in Childhood·Amanda L WilkinsAmanda Gwee
Mar 2, 2002·Revista Da Sociedade Brasileira De Medicina Tropical·Gerusa DreyerJoaquim Noroes
Jul 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·S A WilliamsJ P Moulia-Pelat
Jul 1, 1997·Cadernos de saúde pública·G Dreyer, G Coelho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.