Advantages of positron emission tomography over computed tomography in mediastinal staging of non-small cell lung cancer

The Journal of Surgical Research
Derek W von HaagTracy M Taylor

Abstract

New treatment algorithms in early stage non-small cell lung cancer (NSCLC) involving preoperative chemotherapy require accurate clinical staging of the mediastinum. This study compares the accuracy of 2-[fluorine-18]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) scanning with that of computed tomography (CT) scanning in the clinical staging of non-small cell lung cancer. A retrospective review was performed on 52 patients with NSCLC who were evaluated with both CT and PET scans. All patients had their mediastinal lymph nodes sampled by mediastinoscopy or at the time of thoracotomy for pulmonary resection. Each imaging study was evaluated separately and correlated with histopathologic results. For detecting mediastinal metastases the sensitivities of PET and CT scans were 67 and 50%, respectively; specificities were 91 and 65%, respectively; accuracies were 88 and 63%, respectively; positive predictive values were 50 and 16%, respectively; negative predictive values were 95 and 88%, respectively. PET scans were significantly better than CT scans at detecting mediastinal metastases (PET, 4/8; CT, 3/19) (P = 0.01). PET scanning is superior to CT scanning for clinical staging of the mediastinum in NSCLC. A more c...Continue Reading

Citations

Nov 29, 2007·Journal of the National Cancer Institute·Yee C UngUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care
Oct 28, 2006·American Journal of Respiratory and Critical Care Medicine·Pankaj SinghRichard A Erickson
Oct 24, 2013·Multidisciplinary Respiratory Medicine·Mehmet Akif OzgülMahmut Yüksel
Oct 28, 2005·Radiology·Reginald F MundenDavid J Stewart
Sep 27, 2003·Radiology·Gerald AntochLutz S Freudenberg
Mar 5, 2008·Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery·Karl-Hans Englmeier, Marcus D Seemann
Oct 6, 2007·Chest·Gerard A SilvestriUNKNOWN American College of Chest Physicians
Aug 28, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andrij AbramyukNasreddin Abolmaali
Jul 6, 2011·Seminars in Roentgenology·Eithne Delappe, Mark Dunphy
Jan 8, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wenfeng YangWanhu Li
Feb 27, 2007·The Journal of Thoracic and Cardiovascular Surgery·Benjamin Enoch LeeDavid Follette
Apr 7, 2007·Journal of the American College of Radiology : JACR·Mylene T TruongBenjamin Movsas
Apr 26, 2005·Radiologic Clinics of North America·Reginald F Munden, John Bruzzi
Dec 24, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David G PfisterUNKNOWN American Society of Clinical Oncology
Jun 14, 2006·Journal of Thoracic Imaging·John F Bruzzi, Reginald F Munden
Sep 24, 2004·The Cancer Journal·Jeffrey T YapDavid W Townsend
Sep 24, 2004·Thoracic Surgery Clinics·Dorith ShahamOrly Goitein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
J M AlbesG Ziemer
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
James R Jett
© 2022 Meta ULC. All rights reserved