Adventitial alterations are the main features in pulmonary artery remodeling due to long-term chronic intermittent hypobaric hypoxia in rats

BioMed Research International
Julio BritoM Rosario López

Abstract

Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and long-term intermittent hypoxia (CIH2x2; 2 days of hypoxia/2 days of normoxia, n = 10) in a chamber (428 Torr, 4,600 m of altitude) for 46 days and compared to rats under normoxia (NX, n = 10). Body weight, hematocrit, and right ventricle ratio were measured. Pulmonary artery remodeling was assessed using confocal microscopy of tissues stained with a nuclear dye (DAPI) and CD11b antibody. Both hypoxic conditions exhibited increased hematocrit and hypertrophy of the right ventricle, tunica adventitia, and tunica media, with no changes in lumen size. The medial hypertrophy area (larger in CH) depicted a significant increase in smooth muscle cell number. Additionally, CIH2x2 increased the adventitial hypertrophy area, with an increased cellularity and a larger prevalence of clustered inflammatory cells. In conclusion, CIH2x2 elicits milder effects on pulmonary artery medial layer muscularization and subsequent right vent...Continue Reading

References

Mar 1, 1974·Clinical Science and Molecular Medicine·C HunterE J Clegg
Dec 1, 1966·The American Journal of Cardiology·R F GroverS G Blount
Jan 1, 1997·Annual Review of Physiology·K R Stenmark, R P Mecham
Apr 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J K BelknapK R Stenmark
Oct 3, 1999·Methods in Enzymology·S M ArribasI C McGrath
Mar 21, 2001·High Altitude Medicine & Biology·F L Powell, N Garcia
Aug 7, 2002·High Altitude Medicine & Biology·John B West
Aug 7, 2002·High Altitude Medicine & Biology·Jean-Paul RichaletAngélica Leòn
Apr 26, 2003·Pflügers Archiv : European journal of physiology·Olivier-Eric MorelJean-Paul Richalet
Sep 4, 2003·The European Respiratory Journal·P DorfmüllerM Humbert
Dec 16, 2003·High Altitude Medicine & Biology·Akpay S SarybaevJan Zielinski
Jul 14, 2004·Chest·Lewis J Rubin, UNKNOWN American College of Chest Physicians
Aug 3, 2005·High Altitude Medicine & Biology·Fabiola León-VelardeGustavo Zubieta-Calleja
Oct 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Víctor I PeinadoJoan A Barberà
Mar 28, 2006·Physiology·Kurt R StenmarkMita Das
May 2, 2007·Current Cardiology Reports·Mobusher Mahmud, Hunter C Champion
Jul 28, 2007·The Journal of Physiology·Silvia M ArribasJohn C McGrath
Nov 28, 2007·Annual Review of Pathology·Marlene Rabinovitch
Jul 4, 2008·The Journal of Clinical Investigation·Marlene Rabinovitch
Dec 2, 2008·The European Respiratory Journal·N SommerN Weissmann
Mar 3, 2009·Progress in Cardiovascular Diseases·Dimitar Sajkov, R Doug McEvoy
May 26, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Danielle L BurkeKurt R Stenmark
Jun 7, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M Victoria CondeSilvia M Arribas
Apr 13, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Trevi A RamirezMerry L Lindsey
Jun 26, 2013·High Altitude Medicine & Biology·David J Welsh, Andrew J Peacock
Apr 11, 2014·BioMed Research International·Patricia SiquesM Rosario López

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Citations

Nov 12, 2015·Frontiers in Neuroscience·Elena Rybnikova, Mikhail Samoilov
Jul 28, 2018·Frontiers in Physiology·Patricia SiquesEduardo Pena
Nov 19, 2020·International Journal of Molecular Sciences·Eduardo PenaÁngel Luis López de Pablo

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Methods Mentioned

BETA
confocal microscopy
dissection

Software Mentioned

Metamorph
SPSS
Metamorph Image analysis

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