Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis

Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]
Louise J Walport, Christopher J Schofield

Abstract

The 2-oxoglutarate (2OG) dependent oxygenases were first identified as having roles in the post-translational modification of procollagen in animals. Subsequently in plants and microbes, they were shown to have roles in the biosynthesis of many secondary metabolites, including signalling molecules and the penicillin/cephalosporin antibiotics. Crystallographic studies of microbial 2OG oxygenases and related enzymes, coupled to DNA sequence analyses, led to the prediction that 2OG oxygenases are widely distributed in aerobic biology. This personal account begins with examples of the roles of 2OG oxygenases in antibiotic biosynthesis, and then describes efforts to assign functions to other predicted 2OG oxygenases. In humans, 2OG oxygenases have been found to have roles in small molecule metabolism, as well as in the epigenetic regulation of protein and nucleic acid biosynthesis and function. The roles and functions of human 2OG oxygenases are compared, focussing on discussion of their substrate and product selectivities. The account aims to emphasize how scoping the substrate selectivity of, sometimes promiscuous, enzymes can provide insights into their functions and so enable therapeutic work.

References

Aug 1, 1992·The Journal of Antibiotics·J E BaldwinC J Schofield
Apr 2, 1973·Biochemical and Biophysical Research Communications·W K Paik, S Kim
Sep 15, 1984·The Biochemical Journal·C P PangE P Abraham
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G L Wang, G L Semenza
Aug 1, 1997·Natural Product Reports·K H BaggaleyC J Schofield
Sep 2, 1998·Nature·K ValegårdI Andersson
Feb 13, 2001·Trends in Biochemical Sciences·P M Clissold, C P Ponting
May 22, 2001·Archives of Biochemistry and Biophysics·Y Y CharngS F Yang
Aug 23, 2001·Trends in Molecular Medicine·G L Semenza
Oct 13, 2001·Science·R K Bruick, S L McKnight
Dec 12, 2001·European Journal of Biochemistry·I J CliftonC J Schofield
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Apr 12, 2002·Journal of Neurochemistry·Anthony S WierzbickiF Brian Gibberd
May 11, 2002·Science·Jung-Hyun MinNikola P Pavletich
Nov 15, 2002·Proceedings of the National Academy of Sciences of the United States of America·Charles E DannJohann Deisenhofer
Nov 26, 2002·The Journal of Biological Chemistry·Jonathan M ElkinsChristopher J Schofield
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Johanna Myllyharju
Jul 23, 2003·Bioorganic & Medicinal Chemistry Letters·David R MoleChristopher J Schofield
Dec 12, 2003·BMC Genomics·Michal A KurowskiJanusz M Bujnicki
May 4, 2004·Nature Reviews. Molecular Cell Biology·Christopher J Schofield, Peter J Ratcliffe
Jul 13, 2004·The Journal of Biological Chemistry·Rebecca J AppelhoffJonathan M Gleadle

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