Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population.

Pituitary
C DimopoulouG K Stalla

Abstract

GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular risk profile in patients with controlled acromegaly and controls. A cross-sectional study. We evaluated anthropometric parameters (height, weight, body mass index (BMI), waist and hip circumference, waist to height ratio) and, additionally, cardiovascular risk biomarkers (fasting plasma glucose, HbA1c, triglycerides, total cholesterol, HDL, LDL, and lipoprotein (a), in 81 acromegalic patients (58% cured) compared to 320 age- and gender-matched controls (ratio 1:4), sampled from the primary care patient cohort DETECT. The whole group of 81 acromegalic patients presented with significantly higher anthropometric parameters, such as weight, BMI, waist and hip circumference, but with more favourable cardiovascular risk biomarkers, such as fasting plasma glucose, total cholesterol, triglycerides and HDL levels, in comparison to their respective controls. Biochemically controlled acromegalic patients again showed signifi...Continue Reading

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Citations

Jan 12, 2011·Pituitary·Jean-Christophe MaizaPhilippe Caron
Jun 17, 2015·International Journal of Endocrinology·Helen M ConaglenJohn V Conaglen
Mar 21, 2017·Frontiers in Endocrinology·Victor J GeraedtsNienke R Biermasz
Aug 20, 2014·The Journal of Clinical Endocrinology and Metabolism·Carlos Reyes-VidalPamela U Freda
May 28, 2020·Reviews in Endocrine & Metabolic Disorders·Thalijn L C WoltersRomana T Netea-Maier

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Software Mentioned

HEENA SAS -
SAS
DETECT
STATA

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