Adverse cardiac events in children with Williams syndrome undergoing cardiovascular surgery: An analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database

The Journal of Thoracic and Cardiovascular Surgery
Christoph P HornikKevin D Hill

Abstract

Patients with Williams syndrome (WS) undergoing cardiac surgery are at risk for major adverse cardiac events (MACE). Prevalence and risk factors for such events have not been well described. We sought to define frequency and risk of MACE in patients with WS using a multicenter clinical registry. We identified cardiac operations performed in patients with WS using the Society of Thoracic Surgeons Congenital Heart Surgery Database (2000-2012). Operations were divided into 4 groups: isolated supravalvular aortic stenosis, complex left ventricular outflow tract (LVOT), isolated right ventricular outflow tract (RVOT), and combined LVOT/RVOT procedures. The proportion of patients with MACE (in-hospital mortality, cardiac arrest, or postoperative mechanical circulatory support) was described and the association with preoperative factors was examined. Of 447 index operations (87 centers), median (interquartile range) age and weight at surgery were 2.4 years (0.6-7.4 years) and 10.6 kg (6.5-21.5 kg), respectively. Mortality occurred in 20 patients (5%). MACE occurred in 41 patients (9%), most commonly after combined LVOT/RVOT (18 out of 87; 21%) and complex LVOT (12 out of 131; 9%) procedures, but not after isolated RVOT procedures. Odd...Continue Reading

References

Dec 1, 1996·The Journal of Pediatrics·L M BirdM C Jones
Dec 22, 2005·The Annals of Thoracic Surgery·Fred H EdwardsUNKNOWN Society of Thoracic Surgeons
Aug 25, 2006·The Annals of Thoracic Surgery·Marshall L JacobsGlenn J Pelletier
Dec 17, 2008·Cardiology in the Young·David R ClarkeJeffrey P Jacobs
Oct 23, 2009·The Journal of Pediatrics·R Thomas CollinsJonathan J Rome
Jan 22, 2010·The New England Journal of Medicine·Barbara R Pober
Mar 10, 2010·The American Journal of Cardiology·R Thomas CollinsJonathan J Rome
Apr 16, 2010·The New England Journal of Medicine·Xavier GameClare J Fowler
Sep 22, 2010·The American Journal of Cardiology·R Thomas CollinsMaully J Shah
May 10, 2011·The American Journal of Cardiology·R Thomas Collins
Mar 31, 2012·The American Journal of Cardiology·R Thomas CollinsPaige B Kaplan
May 30, 2013·Circulation·R Thomas Collins
Apr 1, 2010·World Journal for Pediatric & Congenital Heart Surgery·Jeffrey Phillip JacobsJames Anthony Quintessenza
Oct 9, 2013·JAMA : the Journal of the American Medical Association·Mary T HawnThomas M Maddox

❮ Previous
Next ❯

Citations

Apr 14, 2016·Case Reports in Anesthesiology·Federico BoncagniFrancesco Ventrella
Jul 12, 2016·Paediatric Anaesthesia·Gregory J LathamDenise C Joffe
Aug 6, 2016·The Annals of Thoracic Surgery·Marshall L JacobsFred H Edwards
Nov 8, 2015·The Journal of Thoracic and Cardiovascular Surgery·Aristotle D Protopapas
Nov 11, 2016·International Journal of Cardiology·Emily J Callander, Robyn McDermott
Mar 31, 2015·The Journal of Thoracic and Cardiovascular Surgery·Jonathan M Chen
Apr 7, 2017·Congenital Heart Disease·R Thomas Collins IiJustin T Hamrick
Jan 20, 2016·Seminars in Cardiothoracic and Vascular Anesthesia·Mark Twite, Richard J Ing
Mar 17, 2018·World Journal for Pediatric & Congenital Heart Surgery·Michael C MongéCarl L Backer
Jul 26, 2018·Current Opinion in Pediatrics·R Thomas Collins
Apr 6, 2019·Cardiology in the Young·Samer Abu-SultanehChristopher W Mastropietro
Feb 28, 2019·Paediatric Anaesthesia·Mark D TwiteRichard J Ing
May 8, 2015·International Journal of Phytoremediation·Hamide Mazaheri, Khosro Piri
Nov 21, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Massimo A PadalinoGiovanni Stellin
Nov 10, 2020·World Journal for Pediatric & Congenital Heart Surgery·Richard D MainwaringFrank L Hanley
Sep 27, 2020·The Journal of Thoracic and Cardiovascular Surgery·Richard D MainwaringFrank L Hanley
Apr 8, 2019·The Journal of Thoracic and Cardiovascular Surgery·Christopher W MastropietroUNKNOWN Collaborative Research in Pediatric Cardiac Intensive Care Investigators
Oct 30, 2021·American Journal of Medical Genetics. Part a·Rachel Sayuri HonjoChong Ae Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.