Adverse cardiovascular effects with acute particulate matter and ozone exposures: interstrain variation in mice.

Environmental Health Perspectives
Ali K HamadeClarke G Tankersley

Abstract

Increased ambient particulate matter (PM) levels are associated with cardiovascular morbidity and mortality, as shown by numerous epidemiology studies. Few studies have investigated the role of copollutants, such as ozone, in this association. Furthermore, the mechanisms by which PM affects cardiac function remain uncertain. We hypothesized that PM and O(3) induce adverse cardiovascular effects in mice and that these effects are strain dependent. After implanting radiotelemeters to measure heart rate (HR) and HR variability (HRV) parameters, we exposed C57Bl/6J (B6), C3H/HeJ (HeJ), and C3H/HeOuJ (OuJ) inbred mouse strains to three different daily exposures of filtered air (FA), carbon black particles (CB), or O(3) and CB sequentially [O(3)CB; for CB, 536 +/- 24 microg/m(3); for O(3), 584 +/- 35 ppb (mean +/- SE)]. We observed significant changes in HR and HRV in all strains due to O(3)CB exposure, but not due to sequential FA and CB exposure (FACB). The data suggest that primarily acute HR and HRV effects occur during O(3)CB exposure, especially in HeJ and OuJ mice. For example, HeJ and OuJ mice demonstrated dramatic increases in HRV parameters associated with marked brady-cardia during O(3)CB exposure. In contrast, depressed H...Continue Reading

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Citations

Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ali K Hamade, Clarke G Tankersley
Jun 2, 2011·Environmental Health Perspectives·Georg E MattMelbourne F Hovell
Sep 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Clarke G TankersleyNicole Sborz
Nov 16, 2012·Inhalation Toxicology·Blake A BennettClarke G Tankersley
May 17, 2011·Environmental Research·Paulo Sérgio ChiarelliLourdes Conceição Martins
May 17, 2014·The Science of the Total Environment·T FontesA C Carvalho
Apr 21, 2009·Particle and Fibre Toxicology·Shrilatha BalakrishnaStephania A Cormier
Aug 13, 2009·Environmental Health Perspectives·Asghar A FakhriMurray A Mittleman

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