Adverse change in low-density lipoprotein subfractions profile with oestrogen-only hormone replacement therapy

QJM : Monthly Journal of the Association of Physicians
I RajmanM J Kendall

Abstract

In a prospective longitudinal study in 17 women, we investigated the effects of surgical menopause and subsequent oestrogen-only hormone replacement therapy (HRT) on plasma concentrations of total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride and LDL subfractions profile. Plasma LDL is a heterogeneous population of particles of varying size, density and chemical composition. The predominance of small LDL particles is a newly-recognized risk factor for coronary artery disease. The LDL score is used to describe LDL subfractions profile and the greater the score, the higher the proportion of small LDL particles. Six weeks after hysterectomy and bilateral oopherectomy, total cholesterol and triglyceride concentrations were significantly increased (p < 0.01) as well as the LDL score (p < 0.05). After 6 weeks of oestrogen-only HRT, total cholesterol concentration was significantly lower and HDL cholesterol concentration significantly higher than before the treatment (p < 0.05). At the same time, mean LDL score significantly increased and in none of the women did LDL subfractions profile change favourably.

Citations

Nov 11, 2008·Climacteric : the Journal of the International Menopause Society·P VillaA Lanzone
Aug 18, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Thomas A HughesFrankie Stentz
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Thelma E PatrickJames M Roberts
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·E EdmundsG Y Lip
Oct 23, 2002·Clinical Endocrinology·V ToescuF Dunne
Apr 14, 2017·Diabetology & Metabolic Syndrome·Marília Izar Helfenstein FonsecaSandra Roberta G Ferreira
Oct 22, 1998·Metabolism: Clinical and Experimental·S VadlamudiH Barakat

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