Adverse childhood experiences (ACEs) and medically traumatic events (TEs) in adolescents and young adults (AYAs) with cancer: a report from the Promoting Resilience in Stress Management (PRISM) randomized controlled trial.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Samantha ScottAbby R Rosenberg

Abstract

In adolescents and young adults (AYAs) with cancer, we examined (1) the distribution and type of traumatic events (TEs) experienced prior to baseline assessment and (2) how a resilience intervention, Promoting Resilience in Stress Management (PRISM), impacted changes in patient-reported outcomes (PROs) for AYAs with and without TEs. AYAs (12-25 years) within 1-10 weeks of diagnosis of new malignancy or ever diagnosed with advanced cancer were enrolled and randomly assigned to usual care (UC) with or without PRISM. To assess TEs, we screened medical records for traditionally defined adverse childhood experiences (ACEs) and medical traumatic events. Age-validated PROs assessed resilience, benefit-finding, hope, generic health-related quality of life (QoL), cancer-specific QoL, depression, and anxiety at enrollment and 6 months later. We calculated effect sizes (Cohen's d) for PRISM vs. UC effect on PRO score change at 6 months for 1+ TEs and 0 TE groups. Ninety-two AYAs enrolled and completed baseline surveys (44-UC, 48-PRISM; N = 74 at 6 months, 38-UC, 36-PRISM); 60% experienced 1+ TEs. PROs at baseline were similar across groups. PRISM's effect on score change was greater (Cohen's d ≥ 0.5) for the 1+ TE group on domains of bene...Continue Reading

References

Apr 1, 1991·Journal of Personality and Social Psychology·C R SnyderP Harney
Jul 1, 1987·The American Journal of Orthopsychiatry·Michael Rutter
Feb 8, 2002·Journal of Psychosomatic Research·Ingvar BjellandDag Neckelmann
Sep 10, 2003·Depression and Anxiety·Kathryn M Connor, Jonathan R T Davidson
Jan 18, 2005·Journal of Pediatric Hematology/oncology·Mariann HedströmLouise von Essen
Jul 7, 2005·Behaviour Research and Therapy·Laura Campbell-SillsMurray B Stein
Jan 11, 2007·Journal of Pediatric Psychology·Sean PhippsJohanna Ogden
Aug 25, 2007·Annual Review of Clinical Psychology·Scott M Monroe
May 20, 2009·Academic Pediatrics·Emalee G FlahertyMark D Everson
Jun 10, 2011·Child Abuse & Neglect·Nadine J BurkeVictor G Carrion
Jul 2, 2011·Clinical Psychology Review·David A MeyersonRyan P Kilmer
Feb 14, 2013·JAMA Pediatrics·David FinkelhorSherry Hamby
May 7, 2013·Child Abuse & Neglect·Monica HodgesNicole Taylor Kletzka
May 8, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Minyoung KwakSteven Cole
May 15, 2015·Journal of Adolescent and Young Adult Oncology·Abby R RosenbergBarbara Jones
Aug 9, 2017·Child Abuse & Neglect·David Finkelhor
Aug 15, 2017·European Journal of Psychotraumatology·Daniela ConradStephan Kolassa
Sep 9, 2017·Journal of Adolescent and Young Adult Oncology·Suzanne R GreupOlga Husson
Oct 3, 2018·Pediatric Blood & Cancer·Abby R RosenbergJoyce P Yi-Frazier

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