Adverse childhood experiences are associated with increased risk of miscarriage in a national population-based cohort study in England.

Human Reproduction
Panayotes DemakakosGita D Mishra

Abstract

Is there an association between adverse childhood experiences (ACE) and the risk of miscarriage in the general population? Specific ACE as well as the summary ACE score were associated with an increased risk of single and recurrent miscarriages. There is scarce evidence on the association between ACE and miscarriage risk. We conducted a retrospective national cohort study. The sample consisted of 2795 women aged 55-89 years from the English Longitudinal Study of Ageing (ELSA). Our study was population-based and included women who participated in the ELSA Life History Interview in 2007. We estimated multinomial logistic regression models of the associations of the summary ACE score and eight individual ACE variables (pertaining to physical and sexual abuse, family dysfunction and experiences of living in residential care or with foster parents) with self-reported miscarriage (0, 1, ≥2 miscarriages). Five hundred and fifty-three women (19.8% of our sample) had experienced at least one miscarriage in their lifetime. Compared with women with no ACE, women with ≥3 ACE were two times more likely to experience a single miscarriage in their lifetime (relative risk ratio 2.00, 95% CI 1.25-3.22) and more than three times more likely to e...Continue Reading

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Citations

May 1, 2021·International Journal of Environmental Research and Public Health·Jordan L ThomasShayna D Cunningham

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Methods Mentioned

BETA
bilateral oophorectomy

Software Mentioned

ELSA

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