Adverse childhood experiences: Basics for the paediatrician

Paediatrics & Child Health
Gabriella JacobPeter D Wong

Abstract

In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress response. A scientific framework provides explanation for numerous childhood and adult health problems and high-risk behaviours that originate in early life. In our review, we discuss adverse childhood experiences, toxic stress, the neurobiological basis and multigenerational and epigenetic transmission of trauma and recognized health implications. Further, we outline building resilience, screening in the clinical setting, primary care interventions, applying trauma-informed care and future directions. We foresee that enhancing knowledge of the far-reaching effects of adverse childhood events will facilitate mitigation of toxic stress, promote child and family resilience and optimize life course health trajectories.

References

Jul 30, 2002·Archives of Pediatrics & Adolescent Medicine·Rachel P BergerElsie Broussard
Sep 17, 2004·Health Affairs·Christopher B Forrest, Anne W Riley
Oct 7, 2004·Pediatrics·Iris Wagman BorowskyMarjorie Ireland
Aug 3, 2006·Maternal & Child Nutrition·Peter D GluckmanCatherine Pinal
May 7, 2008·Archives of Pediatrics & Adolescent Medicine·Judith A CohenAnthony P Mannarino
May 20, 2009·Academic Pediatrics·Emalee G FlahertyMark D Everson
Nov 5, 2009·Pediatrics·Paula Braveman, Colleen Barclay
Dec 28, 2011·Pediatrics·Andrew S GarnerUNKNOWN Section on Developmental and Behavioral Pediatrics
Dec 28, 2011·Pediatrics·Jack P ShonkoffUNKNOWN Section on Developmental and Behavioral Pediatrics
Jan 23, 2013·Pediatrics·Sara B JohnsonJenna Riis
Feb 14, 2013·JAMA Pediatrics·David FinkelhorSherry Hamby
May 7, 2013·JAMA Pediatrics·Emalee G FlahertyDesmond K Runyan
Oct 11, 2014·American Journal of Preventive Medicine·Leah K GilbertSharyn E Parks
Jul 18, 2015·Academic Pediatrics·Andrew S GarnerMoira Szilagyi
Aug 25, 2015·American Journal of Preventive Medicine·Peter F CronholmJoel A Fein
Sep 8, 2015·Academic Pediatrics·Moira Szilagyi, Neal Halfon
Nov 17, 2015·JAMA Pediatrics·Meghan L MarsacJoel Fein
Feb 10, 2016·JAMA Pediatrics·Megan H Bair-Merritt, Barry Zuckerman
Jul 19, 2016·Advances in Pediatrics·Monica BucciNadine Burke Harris
May 31, 2017·Pediatrics·Flora Traub, Renée Boynton-Jarrett
Sep 4, 2017·Academic Pediatrics·Bradley Planey
Sep 4, 2017·Academic Pediatrics·Robert D Sege, Charlyn Harper Browne

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Citations

Feb 4, 2021·International Journal of Environmental Research and Public Health·Florencia Barreto-ZarzaEnrique B Arranz-Freijo

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