Adverse childhood experiences influence white matter microstructure in patients with schizophrenia

Psychiatry Research
Sara PolettiFrancesco Benedetti

Abstract

Integrity of brain white matter (WM) tracts in adulthood could be detrimentally affected by exposure to adverse childhood experiences (ACE). Changes of diffusion tensor imaging (DTI) measures suggesting WM disruption have been reported in patients with schizophrenia together with a history of childhood maltreatment. We therefore hypothesized that ACE could be associated with altered DTI measures of WM integrity in patients with schizophrenia. We tested this hypothesis in 83 schizophrenia patients using whole brain tract-based spatial statistics in the WM skeleton with threshold-free cluster enhancement of DTI measures of WM microstructure: axial, radial, and mean diffusivity (MD), and fractional anisotropy (FA). We observed an inverse correlation between severity of ACE and DTI measures of FA, and a positive correlation with MD in several WM tracts including corona radiata, thalamic radiations, corpus callosum, cingulum bundle, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus. Lower FA and higher MD are indexes of a reduction in fibre coherence and integrity. The association of ACE to reduced FA and increased MD in key WM tracts contributing to the functional integrity of the brain sug...Continue Reading

References

Jul 1, 1991·Archives of General Psychiatry·A J SaykinP Stafiniak
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Dec 1, 1996·Radiology·C PierpaoliG Di Chiro
Aug 27, 1998·Schizophrenia Bulletin·M S Buchsbaum, E A Hazlett
Apr 10, 1999·Archives of General Psychiatry·K O LimA Pfefferbaum
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·M S BuchsbaumT C Wei
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Jan 25, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·J FoongM A Ron
Mar 29, 2001·Microscopy Research and Technique·B Soliven
May 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T E NordahlN Kusubov
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 31, 2002·Schizophrenia Research·Darren W HolowkaAlain Brunet
May 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·J BurnsS M Lawrie
Jun 5, 2003·Nature Reviews. Neuroscience·Denis Le Bihan
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Jan 28, 2004·Biological Psychiatry·Warren D TaylorJames R MacFall
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hui-Dong WangAriel Y Deutch
Jul 9, 2004·Archives of General Psychiatry·Daniela HublThomas Dierks
Sep 30, 2004·Journal of Cognitive Neuroscience·Zoltan NagyTorkel Klingberg
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Apr 6, 2005·Archives of General Psychiatry·Jeffrey A LiebermanUNKNOWN HGDH Study Group
Jun 18, 2005·NeuroImage·Lindsay SnookChristian Beaulieu
Jul 19, 2005·Journal of Psychiatric Research·Marek KubickiMartha E Shenton
Aug 16, 2005·Biophysical Journal·Pabitra N Sen, Peter J Basser
Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·David S TuchH Diana Rosas
Feb 8, 2006·Biological Psychiatry·Shelley E TaylorMatthew D Lieberman
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Oct 20, 2006·Neuroscience·R Káradóttir, D Attwell
Nov 14, 2006·Schizophrenia Research·Siew E ChuaGráinne M McAlonan
Dec 8, 2006·Schizophrenia Research·Paul G NestorMartha E Shenton
Feb 9, 2007·Psychiatric Services : a Journal of the American Psychiatric Association·Stanley D RosenbergFrancine Cournos

❮ Previous
Next ❯

Citations

Mar 20, 2016·Jornal de pediatria·Dioclécio Campos Júnior
Jun 3, 2016·Journal of Affective Disorders·Francesco BenedettiHemmo A Drexhage
Jun 4, 2018·Schizophrenia Bulletin·Laila AsmalRobin Emsley
Jun 5, 2019·Neuroscience and Biobehavioral Reviews·Aïda CancelEric Fakra

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.