Adverse clinical and obstetric outcomes among pregnant women with different sickle cell disease genotypes

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Flávia A C SilvaAriani Impieri Souza

Abstract

To compare clinical and obstetric adverse events among pregnant women with sickle cell disease (SCD) according to genotype. The present cross-sectional study enrolled women aged 15-49 years with SCD and prior pregnancy attending a hematology center in Recife, Brazil, between September 1, 2015, and April 30, 2016. Associations between sickle cell genotype (HbSS, HbSC, Sβ-thalassemia) and adverse events were evaluated. Overall, 89 women were included; 74 (83%) had HbSS genotype, 8 (9%) had HbSC genotype, and 7 (8%) had Sβ-thalassemia genotype. Fifty-three (60%) self-reported being of mixed race, and 27 (30%) self-reported they were black. Blood transfusion was observed more frequently among women with HbSS than among those with HbSC genotype (P=0.007). Postpartum adverse events were more frequent in the Sβ-thalassemia than in the HbSS group (P=0.030). Fetal intrauterine death occurred only among women with the HbSS genotype (11 [15%]). In the HbSS group, there was a higher frequency of blood transfusion (P=0.004) and lower rate of spontaneous abortion (P=0.001) among women with six or more consultations. The HbSS genotype was associated with a higher frequency of blood transfusion. Sβ-thalassemia was associated with a higher freq...Continue Reading

References

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Citations

Apr 3, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Elie NkwabongThéophile Nana Njamen
Jul 22, 2021·Revista gaúcha de enfermagem·Evelyne Nascimento PedrosaAriani Impieri Souza

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