Abstract
To compare clinical and obstetric adverse events among pregnant women with sickle cell disease (SCD) according to genotype. The present cross-sectional study enrolled women aged 15-49 years with SCD and prior pregnancy attending a hematology center in Recife, Brazil, between September 1, 2015, and April 30, 2016. Associations between sickle cell genotype (HbSS, HbSC, Sβ-thalassemia) and adverse events were evaluated. Overall, 89 women were included; 74 (83%) had HbSS genotype, 8 (9%) had HbSC genotype, and 7 (8%) had Sβ-thalassemia genotype. Fifty-three (60%) self-reported being of mixed race, and 27 (30%) self-reported they were black. Blood transfusion was observed more frequently among women with HbSS than among those with HbSC genotype (P=0.007). Postpartum adverse events were more frequent in the Sβ-thalassemia than in the HbSS group (P=0.030). Fetal intrauterine death occurred only among women with the HbSS genotype (11 [15%]). In the HbSS group, there was a higher frequency of blood transfusion (P=0.004) and lower rate of spontaneous abortion (P=0.001) among women with six or more consultations. The HbSS genotype was associated with a higher frequency of blood transfusion. Sβ-thalassemia was associated with a higher freq...Continue Reading
References
Aug 17, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Graham R SerjeantMinerva Thame
Jun 24, 2008·Bulletin of the World Health Organization·Bernadette Modell, Matthew Darlison
Dec 17, 2009·Hematology·Russell E Ware, Banu Aygun
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Dennie T Rogers, Robert Molokie
Jan 6, 2011·Indian Journal of Human Genetics·Malay B MukherjeeRoshan B Colah
Jun 6, 2012·The American Journal of Tropical Medicine and Hygiene·Nana O WilsonJonathan K Stiles
Jul 18, 2014·Revista brasileira de hematologia e hemoterapia·Patrícia Santos Resende CardosoMarcos Borato Viana
Jul 30, 2014·Transfusion·Suheyl AsmaHakan Ozdogu
Aug 15, 2014·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Randa ShahineMiguel Abboud
Dec 19, 2014·British Journal of Haematology·Eugene Oteng-NtimJo Howard
Feb 20, 2015·Hematology·Kim Smith-Whitley
Mar 25, 2015·Blood·Eugene Oteng-NtimLucy C Chappell
Nov 28, 2018·The Cochrane Database of Systematic Reviews·Abiola Olowoyeye, Charles I Okwundu
Citations
Apr 3, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Elie NkwabongThéophile Nana Njamen
Jun 15, 2021·British Journal of Haematology·A Kinga MalinowskiNadine Shehata
Jul 22, 2021·Revista gaúcha de enfermagem·Evelyne Nascimento PedrosaAriani Impieri Souza