PMID: 7544858Sep 9, 1995Paper

Adverse cutaneous reactions to thiacetazone for tuberculosis treatment in Tanzania

Y A IpugeD A Enarson


Because thiacetazone has been linked with serious adverse cutaneous reactions, we undertook 1 year of systematic surveillance for cutaneous thiacetazone-associated adverse reactions within the national tuberculosis programme of Tanzania. For individual cases, we collected information on age, sex, interval between commencing thiacetazone-containing treatment and occurrence of adverse reaction, most severe clinical presentation (toxic epidermal necrolysis, rash without necrolysis, itching without rash), and outcome (dead or alive) within 2 weeks of onset. Univariate and multivariate analyses were done of variables relevant to outcome. 1273 patients with adverse reactions were reported. The frequency of fatal outcome from any cutaneous reaction was 3.1 per 1000 among all tuberculosis patients, and 19.1% among patients with toxic epidermal necrolysis. About 60% of all adverse reactions and deaths occurred within 20 days of starting thiacetazone. Case fatality from adverse cutaneous reactions was considerably less frequent than reported previously, suggesting that improved management might allow retention of thiacetazone in the armamentarium of national tuberculosis programmes even where infection with HIV is prevalent.


Jan 1, 1991·The American Review of Respiratory Disease·P P ErikiT M Daniel
Sep 1, 1990·BMJ : British Medical Journal·A M ElliottK P McAdam
May 1, 1989·The American Review of Respiratory Disease·R L ColebundersH L Francis
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R N Husson, R A Young
Sep 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·P NunnP Winstanley
Jan 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·P KellyG Sipatunyana
Apr 1, 1994·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·C LuoA Zumla
Jun 1, 1993·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M DattaR Prabhakar

❮ Previous
Next ❯


Jan 1, 1997·Pharmacology & Therapeutics·A D Harries
Oct 25, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Asvi A FrancoisElizabeth A Shephard
Jul 1, 2009·Future Medicinal Chemistry·Leonard V Sacks, Rachel E Behrman
Aug 1, 1996·American Journal of Public Health·K M De Cock
Aug 1, 1996·American Journal of Public Health·J E Fielding
Jan 1, 1997·Journal of Clinical Gastroenterology·P M RathiR H Kalro
Jul 13, 2004·Clinical and Experimental Dermatology·A J KanwarB Kumar
Apr 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·H L Rieder, D A Enarson
Aug 17, 2006·The Annals of Pharmacotherapy·Daren LinMichael J Rieder
Dec 30, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F M ShahabS Dadashzadeh

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
A M Elliott, S D Foster
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
R C A OnderwaterN P E Vermeulen
The Australasian Journal of Dermatology
S C Bharija, M S Belhaj
© 2021 Meta ULC. All rights reserved