Adverse drug events in the outpatient setting: an 11-year national analysis.

Pharmacoepidemiology and Drug Safety
Florence T BourgeoisKenneth D Mandl

Abstract

Adverse drug events (ADEs) are a common complication of medical care resulting in high morbidity and medical expenditure. Population level estimates of outpatient ADEs are limited. Our objective was to provide national estimates and characterizations of outpatient ADEs and determine risk factors associated with these events. Data are from the National Center for Health Statistics which collects information on patient visits to outpatient clinics and emergency departments throughout the United States. We examined visits between 1995 and 2005 and measured the national annual estimates of and risk factors for outpatient ADEs requiring medical treatment. The national annual number of ADE-related visits was 4 335,990 (95%CI: 4 326 872-4 345 108). Visits for ADEs to outpatient clinics increased over the study period from 9.0 to 17.0 per 1000 persons (p-value for trend < 0.001). In multivariate analyses, factors associated with ADE visits included patient age (OR: 2.13; 95%CI: 1.63-2.79 for 65 years and older), number of medications taken by patient (OR: 1.88; 95%CI: 1.58-2.25 for five medications or more), and female gender (OR: 1.51; 95%CI: 1.34-1.71). Overall, outpatient ADEs resulted in 107,468 (95%CI: 89 011-125 925) hospital adm...Continue Reading

References

Jul 5, 1995·JAMA : the Journal of the American Medical Association·D W BatesR Hallisey
Jan 22, 1997·JAMA : the Journal of the American Medical Association·D C ClassenJ P Burke
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Mar 16, 2000·Journal of General Internal Medicine·T K GandhiD W Bates
Sep 1, 2000·The American Journal of Medicine·J H GurwitzD W Bates
May 10, 2001·JAMA : the Journal of the American Medical Association·R KaushalD A Goldmann
Jul 24, 2001·Archives of Internal Medicine·T S FieldD W Bates
May 10, 2002·Pharmacoepidemiology and Drug Safety·Tom MjörndalRune Dahlqvist
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Jerry H GurwitzDavid W Bates
Apr 18, 2003·The New England Journal of Medicine·Tejal K GandhiDavid W Bates
Jul 3, 2004·BMJ : British Medical Journal·Munir PirmohamedAlasdair M Breckenridge
Nov 24, 2004·The American Journal of Geriatric Pharmacotherapy·Emily R HajjarKenneth E Schmader
Sep 1, 2005·Joint Commission Journal on Quality and Patient Safety·Chunliu ZhanDaniel Stryer
May 30, 2006·The American Journal of Geriatric Pharmacotherapy·Julia K NguyenEunice Lo
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Daniel S BudnitzJoseph L Annest
Sep 18, 2007·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Rainu KaushalDavid W Bates
Jan 22, 2008·The Journal of Pediatrics·Stephanie O ZandiehRainu Kaushal
Sep 30, 2009·Pediatrics·Florence T BourgeoisMichael W Shannon

❮ Previous
Next ❯

Citations

Nov 22, 2011·International Journal of Clinical Pharmacy·Mackenzie WilliamsAndrew C Stafford
Aug 28, 2012·International Journal of Clinical Pharmacy·Lucien RouletFrançoise Ballereau
Nov 20, 2012·Journal of Nutrition in Gerontology and Geriatrics·Roschelle Heuberger
Aug 20, 2011·Journal of Child and Adolescent Psychopharmacology·Daniel J Safer
Jul 25, 2012·Population Health Management·Susan RobinsonDavid Vlahov
Feb 21, 2014·BMJ : British Medical Journal·Anupam B JenaPinar Karaca-Mandic
Oct 26, 2013·American Journal of Pharmaceutical Education·Adam B WoolleyMargarita V DiVall
Dec 7, 2013·International Journal of Clinical Pharmacy·Juha SinnemäkiMarja Airaksinen
May 25, 2013·Journal of the American Medical Informatics Association : JAMIA·Robert ErikssonSøren Brunak
Oct 1, 2013·Expert Opinion on Drug Safety·Robert L MaherEmily R Hajjar
Jan 26, 2016·Journal of Evaluation in Clinical Practice·Natali JokanovicJ Simon Bell
Oct 2, 2012·Journal of the American Pharmacists Association : JAPhA·Daniel R TouchetteScott R Smith
Sep 11, 2012·Journal of the American Medical Directors Association·Gotaro KojimaKamal Masaki
Apr 17, 2012·Clinics in Geriatric Medicine·Bhavik M Shah, Emily R Hajjar
Jun 28, 2014·The Journal of Spinal Cord Medicine·Patrick KitzmanJimmi Hatton Kolpek
Jul 11, 2012·The International Journal of Pharmacy Practice·Mackenzie WilliamsIvan K Bindoff
Mar 19, 2016·Journal of Evaluation in Clinical Practice·Betul OkuyanFikret Vehbi Izzettin
Dec 18, 2014·Journal of the American Geriatrics Society·Terri R FriedDeanna K Martin
Apr 15, 2015·Journal of the American Medical Directors Association·Natali JokanovicJ Simon Bell
May 20, 2015·The Pharmacogenomics Journal·O AlagozK Kasirajan
Feb 11, 2016·Journal of Racial and Ethnic Health Disparities·Avi BaehrDale J Hu
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·Adam L HershAndrew T Pavia
Nov 9, 2014·European Journal of Clinical Pharmacology·Encarnación Blanco-ReinaInmaculada Bellido-Estévez
Sep 7, 2016·Expert Review of Clinical Pharmacology·Kazeem Adeola OshikoyaIdowu Odunayo Senbanjo
Feb 23, 2017·Medicine·Dimitri GassmannEdouard Battegay
Jan 24, 2014·Journal of Psychopharmacology·Jessica MemarziaGiovanni Giaroli
May 31, 2015·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Aaron R DucoffeDale J Hu
Sep 1, 2011·The Annals of Pharmacotherapy·Mackenzie WilliamsJeff D Hughes
Jun 23, 2011·The Annals of Pharmacotherapy·Stephanie V TachéDarren M Ashcroft
Feb 1, 2018·International Journal of Environmental Research and Public Health·Alexandra FragakisVincent Ho
Nov 17, 2017·Basic & Clinical Pharmacology & Toxicology·Marine L AnderssonBirgit Eiermann
Jul 3, 2013·Journal of Cutaneous Medicine and Surgery·Peter KoelblingerSteven R Feldman
Sep 15, 2017·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Pranav MagalGary A Smith
Feb 21, 2016·The Cochrane Database of Systematic Reviews·Mikkel Christensen, Andreas Lundh
Aug 10, 2018·CPT: Pharmacometrics & Systems Pharmacology·Pengyue ZhangLang Li
Sep 28, 2017·PloS One·Fatemeh Saheb Sharif-AskariKheirollah Gholami

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.