PMID: 9161625May 15, 1997Paper

Adverse drug reactions in home care patients receiving nafcillin or oxacillin

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
A F Dahlgren

Abstract

Documented adverse reactions to anti-infective agents in patients of a home infusion company were studied to determine whether the prevalence of reactions was greater in patients receiving nafcillin or oxacillin than in those receiving other i.v. antiinfectives. Data on adverse drug reactions (ADRs) were obtained by reviewing the discharge summaries of all patients who received anti-infective therapy in 1990-1994 and the company's quarterly and annual ADR reports for that period. The occurrence of ADRs per total courses of therapy was calculated for groups of antiinfectives, as were intensity and causality. For ADRs to nafcillin and oxacillin, patient demographics and treatment information and outcomes were reviewed. A total of 2488 courses of anti-infective therapy were documented, and ADRs occurred in 10.9%. Nafcillin and oxacillin accounted for 105 courses, with an ADR rate of 31.4%; 99 patients received one of these drugs and 24 had ADRs, with rash and phlebitis the most common ADRs. Thirty-nine patients receiving nafcillin or oxacillin had documented infection with methicillin-sensitive Staphylococcus aureus. Seventy-five patients receiving nafcillin or oxacillin did not have an ADR; therapy was successful in 62 of these p...Continue Reading

Citations

Oct 26, 1999·The Annals of Pharmacotherapy·L A Fromm, D L Graham
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nizar F MaraqaAna M Alvarez
Mar 19, 2014·Antimicrobial Agents and Chemotherapy·Kimberly G BlumenthalSandra B Nelson
Mar 7, 2018·BMC Infectious Diseases·Natasha E HolmesUNKNOWN VANESSA study group, on behalf of the Australasian Society for Infectious Diseases (ASID) Clinical Research Network (CRN)
Dec 9, 2004·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Pauline M DobsonMark Loewenthal
Sep 10, 2016·Journal of the Pediatric Infectious Diseases Society·James B WoodJason G Newland

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