Adverse Drug Reactions in Pediatric Emergency Medicine

The Annals of Pharmacotherapy
Domitille DarnisPascale Jolliet

Abstract

The pediatric population displays its own pharmacological characteristics, making children vulnerable to adverse drug reactions (ADRs). To determine the incidence of ADRs among the pediatric emergency department (PED) population. This is a descriptive, noncontrolled, prospective, and single-center study, during 4 consecutive months in the PED of Nantes University Hospital. Setting up active gathering of data on ADRs enabled 121 reports of 11 095 consultations at the emergency department, which corresponds to an ADR incidence of 1.09%. Digestive and cutaneous reactions made up the majority of reactions judged as being nonserious (53%) and were mainly found in children between 2 -11 years old. Of the serious ADRs, 25% were found in the 12-15-year-old age range because of the drug overdose. The main medications administered, which were responsible for the majority of the ADRs, were an equimolar mix of oxygen and nitrogen monoxide, amoxicillin, and acetaminophen. Three means of collecting data were possible: collecting files data, oral communication, or filling a form, the last being the most used method. This active data gathering shows the incidence and nature of the adverse effects as well as the age distribution in the PED popu...Continue Reading

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Citations

Jan 31, 2016·The Annals of Pharmacotherapy·Xiulu RuanAlan David Kaye
Mar 23, 2019·International Journal of Nursing Knowledge·Vanessa Monteiro MantovaniEneida Rejane Rabelo-Silva
May 21, 2020·Pharmacoepidemiology and Drug Safety·Malahat KhaliliAli Akbar Haghdoost
Jan 31, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jennifer G KendrickRoxane R Carr

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