Adverse drug reactions in pregnant women

Thérapie
Isabelle LacroixChristine Damase-Michel

Abstract

A Prospective pharmacovigilance survey of adverse drug reactions (ADRs) in pregnant women was performed in collaboration with gynaecologists and obstetricians of Midi-Pyrenees area (south west of france). The aim of the study was to evaluate the incidence of adverse drug reactions in pregnant women. The incidence of ADRs in pregnant women was low: 0.3%. Moreover, a retrospective pharmacoepidemiological study was conducted to characterize ADRs in pregnant women. Reports of ADRs collected in the Midi-Pyrenees pharmacovigilance centre from 1982 to 2002 were used: type of ADRs, drugs involved and potential risk factors were compared for pregnant women and for age-matched non pregnant women. Forty seven and 94 reports of ADRs were collected in pregnant and non-pregnant women respectively. Anaphylactic reactions were only observed in pregnant women (3 cases, p = 0.04). We observed 1 ADR related stillbirth (due to anaphylactic reaction) in pregnant women. Drugs for gynaecological and cardiovascular systems were more frequently involved in ADRs in pregnant women than in controls. ADRs mainly occurred during the third trimester of pregnancy. The incidence of ADRs is very low in pregnant women. However, one must pay attention on the risk...Continue Reading

References

Apr 1, 1984·British Journal of Obstetrics and Gynaecology·B N Walters, C W Redman
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BacqJ Weill
Nov 26, 1998·Clinical Therapeutics·B Larsen, D D Glover
Nov 30, 2000·Lancet·I LacroixJ L Montastruc
Jul 1, 1965·Anesthesiology·J A PRITCHARD

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Citations

Jun 13, 2019·BMC Pregnancy and Childbirth·Kathlen Dayanne Lopes da SilvaRand Randall Martins

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