Adverse drug reactions.

British Journal of Clinical Pharmacology
Yoon K Loke

Abstract

Our ability to understand fully the characteristics of clinically important adverse drug reactions is hindered by a lack of emphasis on biological mechanisms, patient susceptibility factors and long-term outcomes. Assessment of drug safety needs to move beyond industry and regulatory perspectives, towards a greater focus on evidence-based preventive and management strategies that will allow patients and physicians to deal with adverse drug reactions at the bedside. This would ideally involve close collaboration between clinical pharmacologists and pharmacoepidemiologists skilled at interrogating the increasingly sophisticated electronic healthcare databases. In light of the myriad safety scares that are constantly emerging, patients and physicians would be best served by a centrally funded independent network of rapid-response drug safety researchers who can use techniques of teleoanalysis to describe fully the magnitude of risk, the potential biological mechanisms and patients' susceptibility factors.

References

Nov 10, 2000·BMJ : British Medical Journal·S Derry, Y K Loke
Sep 13, 2003·BMJ : British Medical Journal·Nicholas J Wald, Joan K Morris
Nov 25, 2003·BMJ : British Medical Journal·J K Aronson, R E Ferner
May 31, 2007·Diabetes Care·Sonal SinghCurt D Furberg
Dec 17, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Yoon K LokeCurt D Furberg
Feb 25, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jeffrey K AronsonRobin E Ferner
Dec 17, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robin E Ferner, Jeffrey K Aronson
Oct 12, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jeffrey K Aronson, Robin E Ferner

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Citations

May 29, 2015·Expert Review of Clinical Pharmacology·Jeffrey K Aronson
Dec 16, 2019·Progress in Biophysics and Molecular Biology·Arturo Tozzi, David Papo

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