PMID: 15222724Jun 30, 2004Paper

Adverse effect of drug-induced emotional problems on work and daily activities. A principal component as an independent predictor of ADRs in Shanghai patients with osteo-arthropathy taking nabumetone

International Journal of Clinical Pharmacology and Therapeutics
W ShiM Yan

Abstract

To discover principal components among assessed items from the WHO-SF36 survey by principal component analysis (PCA) and then to establish the relationship between the candidate principal component and the incidence of ADRs induced by nabumetone in Shanghai osteoarthropathy patients. A total of 145 patients were interviewed using the WHO-SF36 questionnaire for quality of life (QOL) assessment before the administration of nabumetone. The sub-items of the questionnaire were analyzed using PCA and several comprehensive variables were established. Relationships between these newly formed variables and the overall incidence of adverse drug reactions (ADRs) caused by nabumetone were evaluated using univariate and multivariate analyses. Several principal components were identified and their linear parameters were estimated using PCA. Through univariate analysis, only 1 principal component--"adverse effect on work and daily activities as a result of emotional problems"--was found related to the incidence of ADRs. The odds ratio (OR) was 1.28 with 95% confidence intervals (CI) of 1.11 and 1.48, p = 0.0384. This result was validated using a multivariate logistic analysis performed on all the alternative candidate covariates, including fa...Continue Reading

Citations

Apr 29, 2009·Gynecologic Oncology·Miyun Tsai-TurtonRichard B S Roden
Oct 21, 2004·Mass Spectrometry Reviews·David Smith, Patrik Spanel
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·Cheng LiMir Imran
Jan 10, 2006·IEEE Transactions on Medical Imaging·Evren Asma, Richard M Leahy

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