Adverse effect profile comparison of pain regimens with and without intravenous acetaminophen in total hip and knee arthroplasty patients

SAGE Open Medicine
Alyssa GallipaniGermin Fahim

Abstract

The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking. To determine whether there is a difference in frequency and type of adverse effects between intravenous acetaminophen-treated and non-intravenous acetaminophen-treated patients. Primary safety endpoints included any adverse effect noted in the electronic medical record post-surgically. Secondary endpoints included changes in laboratory values, vital signs, and pain scores. This is a retrospective, matched, cohort study with data collected from electronic medical records. Adverse effects were collected from progress notes, nursing notes, and post-operative notes. Mean pain score was measured by the 11-point visual analog scale over a 72-h period. A total of 609 patients who underwent a total hip or knee replacement were included. In all, 406 patients were treated with intravenous acetaminophen, and 203 patients received medication management without intravenous acetaminophen. More patients treated with intravenous acetaminophen experienced an adverse effect compared to patients who did not receive intravenous acetaminophen (91.63...Continue Reading

References

Mar 15, 2005·Anesthesiology Clinics of North America·Girish P Joshi, Babatunde O Ogunnaike
Dec 8, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Keith A CandiottiNeil Kumar Singla
Apr 25, 2012·Pain Practice : the Official Journal of World Institute of Pain·Neil K SinglaMike A Royal
Nov 7, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Christian ApfelGary M Oderda

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Citations

Jul 20, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Brian M IlfeldJoseph W Boggs
Aug 28, 2020·Journal of Shoulder and Elbow Surgery·Manan S PatelPaul M Sethi
Jul 8, 2021·The Journal of Bone and Joint Surgery. American Volume·Joseph A KaramJavad Parvizi

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