Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion

Spine
Lisa B E ShieldsChristopher B Shields

Abstract

A retrospective review of patients who underwent an anterior cervical fusion using recombinant human bone morphogenetic protein (rhBMP)-2 with an absorbable collagen sponge (INFUSE; Medtronic Sofamor Danek, Minneapolis, MN). To ascertain the complication rate after the use of high-dose INFUSE in anterior cervical fusions. The rhBMP-2 has been primarily investigated in lumbar spine fusions, where it has significantly enhanced the fusion rate and decreased the length of surgery, blood loss, and hospital stay. We present 151 patients who underwent either an anterior cervical discectomy and fusion (n = 138) or anterior cervical vertebrectomy and fusion (n = 13) augmented with high-dose INFUSE between July 2003 and March 2004. The rhBMP-2 (up to 2.1 mg/level) was used in the anterior cervical discectomy and fusions. A total of 35 (23.2%) patients had complications after the use of high-dose INFUSE in the cervical spine. There were 15 patients diagnosed with a hematoma, including 11 on postoperative day 4 or 5, of whom 8 were surgically evacuated. Thirteen individuals had either a prolonged hospital stay (> 48 hours) or hospital readmission because of swallowing/breathing difficulties or dramatic swelling without hematoma. A signific...Continue Reading

Associated Clinical Trials

References

Jan 1, 1976·Clinical Neurosurgery·J M Tew, F H Mayfield
Sep 1, 1984·Surgical Neurology·D C GoodL Wacaser
Sep 1, 1996·Neurosurgery·J P SheehanG A Helm
Feb 29, 2000·Clinical Orthopaedics and Related Research·H S Sandhu
Sep 3, 2002·Spine·John M Wozney
Oct 24, 2002·Journal of Spinal Disorders & Techniques·J Kenneth BurkusThomas A Zdeblick
Jan 1, 1962·Clinical Neurosurgery·R B CLOWARD

❮ Previous
Next ❯

Citations

Mar 28, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rahul VaidyaClifford M Les
Jan 20, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Anthony M T Chau, Ralph J Mobbs
Mar 13, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Masashi MiyazakiAhmet Alanay
Oct 31, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kiril V MladenovRalf Stuecker
Jun 29, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kirk OwensLeah Y Carreon
Jun 8, 2013·Neurosurgical Review·Anthony Minh Tien ChauRalph Jasper Mobbs
Jun 5, 2012·Journal of Materials Science. Materials in Medicine·Shaun W McLaughlinLakshmi S Nair
Dec 17, 2008·Pharmaceutical Research·Esmaiel Jabbari
Sep 10, 2013·Trends in Biotechnology·Susmita BoseAmit Bandyopadhyay
Jan 30, 2010·Injury·Adam L ShimerAlexander R Vaccaro
Feb 24, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mandeep S VirkJay R Lieberman
Apr 26, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Pongkwan SitasuwanQian Wang
May 24, 2007·Tissue Engineering·Marco N HelderPaul I J M Wuisman
Jun 10, 2010·Tissue Engineering. Part a·Weiming LiChia Soo
Dec 7, 2010·Tissue Engineering. Part a·Ronald K SiuChia Soo
May 3, 2011·Tissue Engineering. Part a·Hee Seok YangByung-Soo Kim
May 28, 2011·Tissue Engineering. Part a·Xinli ZhangChia Soo
Jun 14, 2013·Tissue Engineering. Part a·Jia ShenChia Soo
Jun 25, 2013·Tissue Engineering. Part a·Eun Ji ChungRamille N Shah
Sep 10, 2011·Tissue Engineering. Part B, Reviews·Scott J Hollister, William L Murphy
Feb 25, 2010·Journal of Pediatric Orthopedics·Kevin M MacDonaldKenneth J Noonan
Feb 25, 2010·Journal of Pediatric Orthopedics·Matthew E Oetgen, B Stephens Richards

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.