Adverse effects in kidney function, antioxidant systems and histopathology in rats receiving monosodium glutamate diet

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Maria Del Carmen ContiniStella Mahieu

Abstract

We investigated the effects of adding of monosodium glutamate (MSG) to a standard diet on oxidative stress in kidney, nitric oxide excretion, renal ions handling and blood pressure. We examined the association of these changes with the effects on renal histology. The study was performed on male Wistar rats (5 weeks old) divided into 3 groups: 1) MSG group were fed a diet supplemented with 3g of MSG/kg b.w./day, five days a week, and spontaneous ingestion of a 1% MSG solution during 16 weeks; 2) NaCl group were fed a diet with NaCl (1g/kg b.w./day) and 0.35% NaCl solution permanently alone at the same frequency and time; 3) control group were fed the normal chow and tap water. Sodium, potassium, calcium, phosphorus, creatinine, protein and nitric oxide excretion were analyzed in urine. We utilized clearance techniques to examine glomerular filtration rate and cortical renal plasma flow. We determined the oxidative state and the histopathological changes of renal tissue. Following MSG treatment, absolute and fractional sodium and potassium excretion decreased although there was hyperfiltration. The MSG group showed similar increase in blood pressure than the NaCl group, but nitric oxide excretion was significantly reduced. Althou...Continue Reading

Citations

Dec 10, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Daniel Tomé
Dec 18, 2020·Anais Da Academia Brasileira De Ciências·KÉsia ZanuzoJoÃo Paulo A Amorim
Jan 14, 2021·Scientific Reports·Michele CelestinoCarla Mucignat-Caretta

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