Adverse effects information in clinical guidelines on pharmacological treatment of depression in children and adolescents: a systematic review

BMJ Open
Tone WestergrenMarianne Klemp

Abstract

To analyse to what extent clinical practice guidelines on drug treatment of depression in children and adolescents mention the risk of adverse effects, to characterise the citations in the guidelines and to assess to what extent data from a major study (Treatment for Adolescents With Depression Study, TADS) was used as basis for information about adverse effects. Systematic review of clinical guidelines and clinical decision support tools. PubMed, EMBASE, guideline collections, Health libraries. We included national guidelines on depression in children and adolescents from European and/or English-speaking countries, published in English, German, French or any Scandinavian language since 2008. We also included well-known, international clinical decision support tools. Guidelines were examined by all authors to identify and classify information on adverse effects. Citations for statements on adverse effects were extracted and classified by category. The extent of citations about suicidality risk versus other adverse effects was assessed. 19 guidelines were assessed. All guidelines discussed risk of suicidal behaviour connected with use of antidepressants. Most guidelines mentioned some other psychiatric adverse effects. Several g...Continue Reading

References

Aug 19, 2004·JAMA : the Journal of the American Medical Association·John MarchUNKNOWN Treatment for Adolescents With Depression Study (TADS) Team
Dec 1, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Graham EmslieUNKNOWN TADS Team
Jul 7, 2007·BMC Medical Research Methodology·Yoon K LokeUNKNOWN Cochrane Adverse Effects Methods Group
Feb 4, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Corrado BarbuiAndrea Cipriani
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Jul 7, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Melissa C BrouwersUNKNOWN AGREE Next Steps Consortium
Jan 5, 2011·Journal of Clinical Epidemiology·Gordon GuyattHolger J Schünemann
Nov 17, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Berit Grøholt
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Romy HurwitzSusan Woolfenden
Jan 15, 2013·Journal of Clinical Epidemiology·Jeff AndrewsHolger J Schünemann
Jan 10, 2014·BMJ : British Medical Journal·Liliane ZorzelaSunita Vohra
Nov 25, 2014·BMJ : British Medical Journal·Pooja SainiJamie J Kirkham
Oct 27, 2015·Social Psychiatry and Psychiatric Epidemiology·S M CottonP D McGorry
Feb 23, 2019·BMC Psychiatry·Jessica Hanae Zafra-TanakaAlvaro Taype-Rondan

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Methods Mentioned

BETA
sedation

Software Mentioned

Appraisal of Guidelines for Research & Evaluation II ( AGREE II )
DynaMed
EMBASE
GRADE
PRISMA
AGREE

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